Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.

Abstract : Although optimal control theory has been used for the theoretical study of anti-cancerous drugs scheduling optimization, with the aim of reducing the primary tumor volume, the effect on metastases is often ignored. Here, we use a previously published model for metastatic development to define an optimal control problem at the scale of the entire organism of the patient. In silico study of the impact of different scheduling strategies for anti-angiogenic and cytotoxic agents (either in monotherapy or in combination) is performed to compare a low-dose, continuous, metronomic administration scheme with a more classical maximum tolerated dose schedule. Simulation results reveal differences between primary tumor reduction and control of metastases but overall suggest use of the metronomic protocol.
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Article dans une revue
Journal of Theoretical Biology, Elsevier, 2013, 335, pp.235-44. 〈10.1016/j.jtbi.2013.06.036〉
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Contributeur : Sebastien Benzekry <>
Soumis le : jeudi 20 juin 2013 - 12:03:57
Dernière modification le : lundi 12 février 2018 - 20:32:07
Document(s) archivé(s) le : samedi 21 septembre 2013 - 04:08:09

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Sebastien Benzekry, Philip Hahnfeldt. Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.. Journal of Theoretical Biology, Elsevier, 2013, 335, pp.235-44. 〈10.1016/j.jtbi.2013.06.036〉. 〈hal-00836032〉

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