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Non Ribosomal Peptides : A monomeric puzzle

Abstract : Nonribosomal peptides (NRPs) are increasingly studied because they harbor activities which can be exploited in various domains. They are often denoted as graphs illustrating their chemical structure, where the atoms are represented by nodes and the chemical bonds by arcs. Another possible representation is the monomeric structure. This structure, inspired by the biosynthetic pathway of these peptides, is effectuated by large enzymatic complexes which assemble together smaller compounds called monomers. Consequently, the nonribosomal peptides are composed of a great variety of monomers (more than 500 are known) including amino acids, lipids and carbohydrates. Likewise, nonpetidic bonds are formed between multiple monomers, producing peptides with cycles and/or branches. Thus, the monomeric structure is a graph formed by the monomers present in the peptide and their interlinking chemical bonds. Until now, there did not exist a tool allowing for the conversion between the atomic and monomeric structures. This article presents a novel algorithm capable of localising the monomers from a reference list in the chemical structures of peptides extracted from the Norine database. The algorithm is based on a heuristic that utilizes chemical information of NRPs. The preliminary results are encouraging, and should lead to further studies.
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Submitted on : Friday, July 12, 2013 - 11:20:11 AM
Last modification on : Wednesday, February 2, 2022 - 3:56:02 PM
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  • HAL Id : hal-00843827, version 1


Yoann Dufresne, Valérie Leclère, Philippe Jacques, Laurent Noé, Maude Pupin. Non Ribosomal Peptides : A monomeric puzzle. JOBIM - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2013, Toulouse, France. pp.143-150. ⟨hal-00843827⟩



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