The anesthetic propofol shifts the frequency of maximum spectral power in EEG during general anesthesia: analytical insights from a linear model

Axel Hutt 1
1 NEUROSYS - Analysis and modeling of neural systems by a system neuroscience approach
Inria Nancy - Grand Est, LORIA - AIS - Department of Complex Systems, Artificial Intelligence & Robotics
Abstract : The work introduces a linear neural population model that allows to derive analytically the power spectrum subjected to the concentration of the anesthetic propofol. The analytical study of the power spectrum of the systems activity gives conditions on how the frequency of maximum power in experimental electroencephalographic (EEG) changes dependent on the propofol concentration. In this context, we explain the anesthetic-induced power increase in neural activity by an oscillatory instability and derive conditions under which the power peak shifts to larger frequencies as observed experimentally in EEG. Moreover the work predicts that the power increase only occurs while the frequency of maximum power increases. Numerically simulations of the systems activity complement the analytical results.
Document type :
Journal articles
Complete list of metadatas

Cited literature [28 references]  Display  Hide  Download

https://hal.inria.fr/hal-00845833
Contributor : Axel Hutt <>
Submitted on : Wednesday, July 17, 2013 - 10:48:46 PM
Last modification on : Tuesday, December 18, 2018 - 4:40:21 PM
Long-term archiving on : Friday, October 18, 2013 - 4:37:45 AM

File

fncom-07-00002_1_.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Axel Hutt. The anesthetic propofol shifts the frequency of maximum spectral power in EEG during general anesthesia: analytical insights from a linear model. Frontiers in Computational Neuroscience, Frontiers, 2013, ⟨10.3389/fncom.2013.00002⟩. ⟨hal-00845833⟩

Share

Metrics

Record views

327

Files downloads

294