The anesthetic propofol shifts the frequency of maximum spectral power in EEG during general anesthesia: analytical insights from a linear model - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Computational Neuroscience Year : 2013

The anesthetic propofol shifts the frequency of maximum spectral power in EEG during general anesthesia: analytical insights from a linear model

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Abstract

The work introduces a linear neural population model that allows to derive analytically the power spectrum subjected to the concentration of the anesthetic propofol. The analytical study of the power spectrum of the systems activity gives conditions on how the frequency of maximum power in experimental electroencephalographic (EEG) changes dependent on the propofol concentration. In this context, we explain the anesthetic-induced power increase in neural activity by an oscillatory instability and derive conditions under which the power peak shifts to larger frequencies as observed experimentally in EEG. Moreover the work predicts that the power increase only occurs while the frequency of maximum power increases. Numerically simulations of the systems activity complement the analytical results.
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Dates and versions

hal-00845833 , version 1 (17-07-2013)

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Axel Hutt. The anesthetic propofol shifts the frequency of maximum spectral power in EEG during general anesthesia: analytical insights from a linear model. Frontiers in Computational Neuroscience, 2013, ⟨10.3389/fncom.2013.00002⟩. ⟨hal-00845833⟩
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