The response of a population of classical Hodgkin-Huxley neurons to an inhibitory pulse

Abstract : A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30–80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchronization by an inhibitory input pulse often fails for populations of classical Hodgkin–Huxley neurons. Our reasoning suggests that in general, synchronization by inhibitory input pulses can fail when the transition of the target neurons from rest to spiking involves a Hopf bifurcation, especially when inhibition is shunting, not hyperpolarizing. Surprisingly, synchronization is more likely to fail when the inhibitory pulse is stronger or longer-lasting. These findings have potential implications for the question which neurons participate in brain rhythms, in particular in gamma oscillations.
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Journal of Computational Neuroscience, Springer Verlag, 2010, 28 (3), pp.509-526. 〈10.1007/s10827-010-0233-8〉
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Contributeur : Martin Krupa <>
Soumis le : jeudi 18 juillet 2013 - 12:54:48
Dernière modification le : vendredi 25 mai 2018 - 12:02:05

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C. Börgers, Martin Krupa, S. Gielen. The response of a population of classical Hodgkin-Huxley neurons to an inhibitory pulse. Journal of Computational Neuroscience, Springer Verlag, 2010, 28 (3), pp.509-526. 〈10.1007/s10827-010-0233-8〉. 〈hal-00845990〉

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