Qualitative control of genetic networks: the bistable switch example

Madalena Chaves 1 Jean-Luc Gouzé 1
1 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : The control of a generic model for a genetic network is studied using piecewise affine systems. It is assumed that the state measurements are qualitative (each variable is at high or low concentration) and that the possible input values are also qualitative (no control, high or low value). The advantage of this approach is to obtain control laws which can be implemented in the laboratory, using only qualitative knowledge of the system's variables. Exact solutions are given for the problem of controlling the bistable switch to either of its steady states.
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Submitted on : Tuesday, July 23, 2013 - 11:22:32 AM
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Madalena Chaves, Jean-Luc Gouzé. Qualitative control of genetic networks: the bistable switch example. 8th IFAC Symposium on Nonlinear Control Systems (NOLCOS 2010), 2010, Bologna, Italy. pp.338-343, ⟨10.3182/20100901-3-IT-2016.00166⟩. ⟨hal-00847280⟩

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