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Comparing Boolean and piecewise affine differential models for genetic networks

Madalena Chaves 1, * Laurent Tournier 2 Jean-Luc Gouzé 1 
* Corresponding author
1 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : Multi-level discrete models of genetic networks, or the more general piecewise affine differential models, provide qualitative information on the dynamics of the system, based on a small number of parameters (such as synthesis and degradation rates). Boolean models also provide qualitative information, but are based simply on the structure of interconnections. To explore the relationship between the two formalisms, a piecewise affine differential model and a Boolean model are compared, for the carbon starvation response network in E. coli. The asymptotic dynamics of both models are shown to be quite similar. This study suggests new tools for analysis and reduction of biological networks.
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Madalena Chaves, Laurent Tournier, Jean-Luc Gouzé. Comparing Boolean and piecewise affine differential models for genetic networks. Acta Biotheoretica, Springer Verlag, 2010, 58 (2-3), pp.217-232. ⟨10.1007/s10441-010-9097-6⟩. ⟨hal-00847281⟩



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