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Cell cycle modelling for microalgae grown under light/dark cycles

Christophe Mocquet 1 Olivier Bernard 2 Antoine Sciandra 1, 2 
2 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : Microalgae are photosynthetic microorganisms of growing industrial importance. Under natural illumination, they synchronize on the light signal, generating thus complex dynamics. A new model is proposed to represent the cell cycle dynamics of cells submitted to a light-dark signal. The model is based on a Droop approach relating the growth rate (in terms of carbon uptake) with the nitrogen status of the cell. Three main states are considered within the cell cycle: G1, G2 and M. The transition rate from one state to another is assumed to depend on the nutrient status (from G1 to G2) or on the light dose (from G2 to M). The model is then calibrated with experiments performed in various conditions of light and nitrogen supply. The model turns out to accurately represent the cell cycle dynamics, and the carbon fluxes. The model is validated with a data set obtained in slightly different conditions.
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Submitted on : Tuesday, July 23, 2013 - 11:23:12 AM
Last modification on : Sunday, June 26, 2022 - 9:12:58 AM

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Christophe Mocquet, Olivier Bernard, Antoine Sciandra. Cell cycle modelling for microalgae grown under light/dark cycles. 11th IFAC Symposium on Computer Applications in Biotechnology - CAB, 2010, Leuven, Belgium. pp.174-179, ⟨10.3182/20100707-3-BE-2012.0072⟩. ⟨hal-00847298⟩



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