Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells

Abdou Akkouche 1 Thomas Grentzinger 2 Marie Fablet 1 Claudia Armenise 1 Nelly Burlet 1 Virginie Braman 1 Séverine Chambeyron 2 Cristina Vieira 3
1 LBBE - Laboratoire de Biométrie et Biologie Evolutive
2 IGH - Institut de génétique humaine
3 BAMBOO - An algorithmic view on genomes, cells, and environments
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive
Abstract : Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is however unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required for the somatic silencing of the TE and correlate with an increase in histone H3K9 trimethylation an active tirant copy.
Type de document :
Article dans une revue
EMBO Reports, EMBO Press, 2013, 14 (5), pp.458-64. 〈10.1038/embor.2013.38〉
Liste complète des métadonnées
https://hal.inria.fr/hal-00850319
Contributeur : Marie-France Sagot <>
Soumis le : mardi 6 août 2013 - 10:43:22
Dernière modification le : vendredi 12 octobre 2018 - 09:24:02

Lien texte intégral

openaccess

Identifiants

Collections

INRIA | BAMBOO | ECOFECT | BIOENVIS | BS | UNIV-MONTPELLIER | UNIV-LYON1

Citation

Abdou Akkouche, Thomas Grentzinger, Marie Fablet, Claudia Armenise, Nelly Burlet, et al.. Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells. EMBO Reports, EMBO Press, 2013, 14 (5), pp.458-64. 〈10.1038/embor.2013.38〉. 〈hal-00850319〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

442

Contact


archive-ouverte@inria.fr