Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells

Abdou Akkouche 1 Thomas Grentzinger 2 Marie Fablet 3 Claudia Armenise 1 Nelly Burlet 1 Virginie Braman 1 Séverine Chambeyron 2 Cristina Vieira 4
1 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
2 IGH - Institut de génétique humaine
3 Eléments transposables, évolution, populations
GINSENG - Département génétique, interactions et évolution des génomes [LBBE]
4 BAMBOO - An algorithmic view on genomes, cells, and environments
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is however unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required for the somatic silencing of the TE and correlate with an increase in histone H3K9 trimethylation an active tirant copy.
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Contributor : Marie-France Sagot <>
Submitted on : Tuesday, August 6, 2013 - 10:43:22 AM
Last modification on : Friday, April 19, 2019 - 7:42:38 PM

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Abdou Akkouche, Thomas Grentzinger, Marie Fablet, Claudia Armenise, Nelly Burlet, et al.. Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells. EMBO Reports, EMBO Press, 2013, 14 (5), pp.458-64. ⟨10.1038/embor.2013.38⟩. ⟨hal-00850319⟩

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