Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

Marie Fablet; Emmanuelle Lerat; Rita Rebollo; Béatrice Horard; Nelly Burlet; Sonia Martinez; Emilie Brasset; Eric Gilson; Chantal Vaury; Cristina Vieira

doi:10.1096/fj.08-123513

Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

Marie Fablet Emmanuelle Lerat ¹ Rita Rebollo ² Béatrice Horard ³ Nelly Burlet Sonia Martinez Emilie Brasset ⁴ Eric Gilson ³ Chantal Vaury ⁴ Cristina Vieira ⁵

1 Eléments transposables, évolution, populations

GINSENG - Département génétique, interactions et évolution des génomes [LBBE]

2 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558

3 LBMC - Laboratoire de Biologie Moléculaire de la Cellule

4 GReD - Génétique, Reproduction et Développement - Clermont Auvergne

5 BAMBOO - An algorithmic view on genomes, cells, and environments

Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558

Abstract : Combining genome sequence analysis and functional analysis, we show that some full-length copies of tirant are present in heterochromatic regions in Drosophila simulans and that when tested in vitro, these copies have a functional promoter. However, when inserted in heterochromatic regions, tirant copies are inactive in vivo, and only transcription of euchromatic copies can be detected. Thus, our data indicate that the localization of the element is a hallmark of its activity in vivo and raise the question of genomic invasions by transposable elements and the importance of their genomic integration sites.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal.inria.fr/hal-00850396
Contributor : Marie-France Sagot <>
Submitted on : Tuesday, August 6, 2013 - 1:21:45 PM
Last modification on : Friday, April 19, 2019 - 7:27:56 PM

Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

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Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

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