Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.

Marie Fablet Emmanuelle Lerat 1 Rita Rebollo 1 Béatrice Horard 2 Nelly Burlet Sonia Martinez Emilie Brasset 3 Eric Gilson 2 Chantal Vaury 3 Cristina Vieira 4
1 LBBE - Laboratoire de Biométrie et Biologie Evolutive
2 LBMC - Laboratoire de Biologie Moléculaire de la Cellule
3 GReD - Génétique, reproduction et développement
4 BAMBOO - An algorithmic view on genomes, cells, and environments
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive
Abstract : Combining genome sequence analysis and functional analysis, we show that some full-length copies of tirant are present in heterochromatic regions in Drosophila simulans and that when tested in vitro, these copies have a functional promoter. However, when inserted in heterochromatic regions, tirant copies are inactive in vivo, and only transcription of euchromatic copies can be detected. Thus, our data indicate that the localization of the element is a hallmark of its activity in vivo and raise the question of genomic invasions by transposable elements and the importance of their genomic integration sites.
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Article dans une revue
FASEB Journal, Federation of American Society of Experimental Biology, 2009, 23 (5), pp.1482-9. 〈10.1096/fj.08-123513〉
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https://hal.inria.fr/hal-00850396
Contributeur : Marie-France Sagot <>
Soumis le : mardi 6 août 2013 - 13:21:45
Dernière modification le : jeudi 28 juin 2018 - 14:38:37

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ENS-LYON | INRIA | BAMBOO | PRES_CLERMONT | BIOENVIS | GRED | UNIV-LYON1

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Marie Fablet, Emmanuelle Lerat, Rita Rebollo, Béatrice Horard, Nelly Burlet, et al.. Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila.. FASEB Journal, Federation of American Society of Experimental Biology, 2009, 23 (5), pp.1482-9. 〈10.1096/fj.08-123513〉. 〈hal-00850396〉

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