Skip to Main content Skip to Navigation
New interface
Journal articles

A framework for inter-subject prediction of functional connectivity from structural networks

Abstract : Functional connections between brain regions are supported by structural connectivity. Both functional and structural connectivity are estimated from in-vivo MRI and offer complementary information on brain organisation and function. However, imaging only provides noisy measures, and we lack a good neuroscientific understanding of the links between structure and function. Therefore, inter-subject joint modeling of structural and functional connectivity, the key to multimodal biomarkers, is an open challenge. We present a probabilistic framework to learn across subjects a mapping from structural to functional brain connectivity. Expanding on our previous work, our approach is based on a predictive framework with multiple sparse linear regression. We rely on the randomized LASSO to identify relevant anatomo-functional links with some confidence interval. In addition, we describe resting-state (rs)-fMRI in the setting of Gaussian graphical models, on the one hand imposing conditional independences from structural connectivity and on the other hand parameterizing the problem in terms of multivariate autoregressive models. We introduce an intrinsic measure of prediction error for functional connectivity that is independent of the parameterization chosen and provides the means for robust model selection. We demonstrate our methodology with regions within the default mode and the salience network as well as, atlas-based cortical parcellation.
Complete list of metadata

Cited literature [70 references]  Display  Hide  Download
Contributor : Gaël Varoquaux Connect in order to contact the contributor
Submitted on : Monday, August 19, 2013 - 6:11:05 PM
Last modification on : Tuesday, January 25, 2022 - 3:11:31 AM
Long-term archiving on: : Wednesday, April 5, 2017 - 9:58:06 PM


Files produced by the author(s)




Fani Deligianni, Gaël Varoquaux, Bertrand Thirion, David J. Sharp, Christian Ledig, et al.. A framework for inter-subject prediction of functional connectivity from structural networks. IEEE Transactions on Medical Imaging, 2013, epub ahead of print, ⟨10.1109/TMI.2013.2276916⟩. ⟨hal-00852072⟩



Record views


Files downloads