Impact of the joint detection-estimation approach on random effects group studies in fMRI - Archive ouverte HAL Access content directly
Conference Papers Year : 2011

Impact of the joint detection-estimation approach on random effects group studies in fMRI

(1, 2) , (2, 3) , (1, 2)
1
2
3

Abstract

Inter-subject analysis of functional Magnetic Resonance Imaging (fMRI) data relies on single intra-subject studies, which are usually conducted using a massively univariate approach. In this paper, we investigate the impact of an improved intra-subject analysis on group studies. basically the joint detection-estimation (JDE) framework where an explicit characterization of the Hemodynamic Response Function (HRF) is performed at a regional scale and a stimulus-specific adaptive spatial correlation model enables the detection of activation clusters at voxel level. For the group statistics, we conducted several Random effect analyses (RFX) which relied either on the General Linear Model (GLM), or on the JDE analyses, or even on an intermediate approach named Spatially Adaptive GLM (SAGLM). Our comparative study perfomed during a fast-event related paradigm involves 18 subjects and illustrates the regionspecific differences between the GLM, SAGLM and JDE analyses in terms of statistical sensitivity. On different contrasts of interest, spatial regularization is shown to have a beneficial impact on the statistical sensitivity. Also, by studying the spatial variability of the HRF, we demonstrate that the JDE framework provides more robust detection performance in cognitive regions due to the higher hemodynamic variability in these areas.
Fichier principal
Vignette du fichier
isbi.pdf (356.35 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-00854626 , version 1 (03-09-2013)

Identifiers

Cite

Solveig Badillo, Thomas Vincent, Philippe Ciuciu. Impact of the joint detection-estimation approach on random effects group studies in fMRI. ISBI 2011 - IEEE Computer Society International Symposium on Biomedical Imaging: From Nano to Macro, Mar 2011, Chicago, United States. pp.376-380, ⟨10.1109/ISBI.2011.5872427⟩. ⟨hal-00854626⟩
699 View
210 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More