Gene tree correction guided by orthology

Manuel Lafond 1, * Magali Semeria 2 Krister Swenson 1, 3 Eric Tannier 2, 4 Nadia El-Mabrouk 1
* Corresponding author
4 BEAGLE - Artificial Evolution and Computational Biology
LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558, Inria Grenoble - Rhône-Alpes, LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
Abstract : Background
Reconciled gene trees yield orthology and paralogy relationships between genes. This information may however contradict other information on orthology and paralogy provided by other footprints of evolution, such as conserved synteny.
Results
We explore a way to include external information on orthology in the process of gene tree construction. Given an initial gene tree and a set of orthology constraints on pairs of genes or on clades, we give polynomial-time algorithms for producing a modified gene tree satisfying the set of constraints, that is as close as possible to the original one according to the Robinson-Foulds distance. We assess the validity of the modifications we propose by computing the likelihood ratio between initial and modified trees according to sequence alignments on Ensembl trees, showing that often the two trees are statistically equivalent.
Availability
Software and data available upon request to the corresponding author.
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Submitted on : Tuesday, October 15, 2013 - 1:09:16 PM
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Manuel Lafond, Magali Semeria, Krister Swenson, Eric Tannier, Nadia El-Mabrouk. Gene tree correction guided by orthology. BMC Bioinformatics, BioMed Central, 2013, 14 (Suppl 15), pp.S5. ⟨hal-00873235⟩

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