SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools

Claudine Chaouiya 1, * Duncan Bérenguier 2 Sarah Keating 3 Aurélien Naldi 4 Martijn Van Iersel 3 Nicolas Rodriguez 3, 5 Andreas Dräger 6, 7 Finja Büchel 7 Thomas Cokelaer 3 Bryan Kowal 8 Benjamin Wicks 9 Emanuel Gonçalves 3 Julien Dorier 10 Michel Page 11, 12, * Pedro Monteiro 1, 13 Axel Von Kamp 14 Ioannis Xenarios 10 Hidde De Jong 12, * Michael Hucka 15 Steffen Klamt 14 Denis Thieffry 16 Nicolas Le Novère 3, 5 Julio Saez-Rodriguez 3, * Tomáš Helikar 8, *
Abstract : Background
Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing.
Results
We present the Systems Biology Markup Language (SBML) Qualitative Models Package ("qual"), an extension of the SBML Level 3 standard designed for computer representation of qualitative models of biological networks. We demonstrate the interoperability of models via SBML qual through the analysis of a specific signalling network by three independent software tools. Furthermore, the collective effort to define the SBML qual format paved the way for the development of LogicalModel, an open-source model library, which will facilitate the adoption of the format as well as the collaborative development of algorithms to analyse qualitative models.
Conclusions
SBML qual allows the exchange of qualitative models among a number of complementary software tools. SBML qual has the potential to promote collaborative work on the development of novel computational approaches, as well as on the specification and the analysis of comprehensive qualitative models of regulatory and signalling networks.
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Soumis le : jeudi 9 janvier 2014 - 09:08:13
Dernière modification le : dimanche 26 août 2018 - 18:16:01
Document(s) archivé(s) le : jeudi 10 avril 2014 - 14:40:24

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Claudine Chaouiya, Duncan Bérenguier, Sarah Keating, Aurélien Naldi, Martijn Van Iersel, et al.. SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools. BMC Systems Biology, BioMed Central, 2013, 7 (1), pp.135. 〈10.1186/1752-0509-7-135〉. 〈hal-00926033〉

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