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Poster communications

Superposition de couches de fibres et propagations anormales : une étude numérique

Simon Labarthe 1, 2 yves Coudière 1, 2 Jacques Henry 2 
1 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, IHU-LIRYC
Abstract : Context : Abrupt variations of fibre directions in the thickness of the atrial tissues have been documented : superimposed fibre layers with different directions have been identified in the left atrium or in the pulmonary veins (PV) and presented as possible sources of perturbation of the electrical conduction. An optical mapping study completed by histological observations on a ventricular swine model showed reentries induced by those type of structure after ischemia. The purpose of this work is to use a numerical model to investigate the consequences of transmural fibre direction heterogeneities on electrical propagation. Method : A bilayer mathematical model that allows to represent heterogeneities of fibre direction is constructed. A numerical implementation is then constructed on a PV geometry that includes transmural heterogeneities of fibres and substrate, consistant with histological and electrophysiological data. S1-S2 stimulation protocols are then applied to model an ectopic source. Results : The abrupt variation of fibre direction from a layer to another triggers a distinct propagation dynamic at depolarization and repolarization times. The propagation is more anisotropic during depolarization, and more isotropic during repolarization, inducing APD gradients and conduction bloc. When this phenomenon is combined with a specific substrate, episodes of complex propagation are observed. Conclusion: The mathematical model that we introduced is able to show that the superimposition of layers with distinct fibre directions is a structure that triggers perturbation of the electrical propagation. This architecture, combined with an altered substrate can induce pathological propagations.
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Poster communications
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https://hal.inria.fr/hal-00926480
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Submitted on : Thursday, January 9, 2014 - 4:08:05 PM
Last modification on : Saturday, June 25, 2022 - 7:44:38 PM
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Simon Labarthe, yves Coudière, Jacques Henry. Superposition de couches de fibres et propagations anormales : une étude numérique. Printemps de la Cardiologie, Apr 2013, Marseille, France. ⟨hal-00926480⟩

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