Abnormal functional connectivity between motor cortex and pedunculopontine nucleus following chronic dopamine depletion.

Miguel Valencia 1 Mario Chavez 2 Julio Artieda 3 J Paul Bolam 4 Juan Mena-Segovia 4
1 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
2 ARAMIS - Algorithms, models and methods for images and signals of the human brain
Inria Paris-Rocquencourt, UPMC - Université Pierre et Marie Curie - Paris 6, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
Abstract : The activity of the basal ganglia is altered in Parkinson's disease (PD) as a consequence of the degeneration of dopamine neurons in the substantia nigra pars compacta. This results in aberrant discharge patterns and expression of exaggerated oscillatory activity across the basal ganglia circuit. Altered activity has also been reported in some of the targets of the basal ganglia, including the pedunculopontine nucleus (PPN), possibly due to its close interconnectivity with most regions of the basal ganglia. However, the nature of the involvement of the PPN in the pathophysiology of PD has not been fully elucidated. Here, we recorded local field potentials in the motor cortex and the PPN in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD under urethane anesthesia. By means of linear and nonlinear statistics, we analyzed the synchrony between the motor cortex and the PPN and the delay in the interaction between these two structures. We observed the presence of coherent activity between the cortex and the PPN in low (5-15 Hz)- and high (25-35 Hz)-frequency bands during episodes of cortical activation. In each case, the cortex led the PPN. Dopamine depletion strengthened the interaction of the low-frequency activities by increasing the coherence specifically in the theta and alpha ranges and reduced the delay of the interaction in the gamma band. Our data show that cortical inputs play a determinant role in leading the coherent activity with the PPN and support the involvement of the PPN in the pathophysiology of PD.
Type de document :
Article dans une revue
Journal of Neurophysiology, American Physiological Society, 2014, 111 (2), pp.434-40. 〈10.1152/jn.00555.2013〉
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Soumis le : mercredi 29 janvier 2014 - 15:13:15
Dernière modification le : jeudi 11 janvier 2018 - 06:25:29

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Miguel Valencia, Mario Chavez, Julio Artieda, J Paul Bolam, Juan Mena-Segovia. Abnormal functional connectivity between motor cortex and pedunculopontine nucleus following chronic dopamine depletion.. Journal of Neurophysiology, American Physiological Society, 2014, 111 (2), pp.434-40. 〈10.1152/jn.00555.2013〉. 〈hal-00938678〉

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