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Neurogenesis in the Striatum of the Adult Human Brain.

Abstract : : In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
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Contributor : Samuel Bernard Connect in order to contact the contributor
Submitted on : Wednesday, February 26, 2014 - 10:04:36 AM
Last modification on : Friday, November 18, 2022 - 9:24:16 AM

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Aurélie Ernst, Kanar Alkass, Samuel Bernard, Mehran Salehpour, Shira Perl, et al.. Neurogenesis in the Striatum of the Adult Human Brain.. Cell, 2014, 156 (5), pp.1072-1083. ⟨10.1016/j.cell.2014.01.044⟩. ⟨hal-00952021⟩



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