A Logical Framework for Systems Biology - Archive ouverte HAL Access content directly
Reports (Research Report) Year : 2014

A Logical Framework for Systems Biology

(1) , (1, 2) , (3)
1
2
3

Abstract

We propose a novel approach for the formal verification of biological systems based on the use of a modal linear logic. We show how such a logic can be used, with worlds as instants of time, as an unified framework to encode both biological systems and temporal properties of their dynamic behaviour. To illustrate our methodology, we consider a model of the P53/Mdm2 DNA-damage repair mechanism. We prove several properties that are important for such a model to satisfy and serve to illustrate the promise of our approach. We formalize the proofs of these properties in the Coq Proof Assistant, with the help of a Lambda Prolog prover for partial automation of the proofs.
Fichier principal
Vignette du fichier
hal-report.pdf (311.31 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-00981409 , version 1 (22-04-2014)

Identifiers

Cite

Elisabetta de Maria, Joelle Despeyroux, Amy Felty. A Logical Framework for Systems Biology. [Research Report] 2014, pp.34. ⟨hal-00981409⟩
218 View
221 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More