Patient-specific modelling of cardiac electrophysiology in heart-failure patients

Mark Potse 1, 2 Dorian Krause 3 Wilco Kroon 3 Romina Murzilli 4 Stefano Muzzarelli 4 François Regoli 4 Enrico G. Caiani 5 Frits W. Prinzen 6 Rolf Krause 2, 3 Angelo Auricchio 2
1 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, IHU-LIRYC
2 Center for Computational Medicine in Cardiology
3 Institute of Computational Science
4 Cardiocentro Ticino [Lugano]
5 Department of Bioengineering [Politecnico Milano]
6 Department of Physiology, Maastricht University
Abstract : Aims Left-ventricular (LV) conduction disturbances are common in heart-failure patients and a left bundle-branch block (LBBB) ECG type is often seen. The precise cause of this pattern is uncertain and is probably variable between patients, ranging from proximal interruption of the left bundle branch to diffuse distal conduction disease in the working myocardium. Using realistic numerical simulation methods and patient-tailored model anatomies we investigated different hypotheses to explain the observed activation order on the LV endocardium, electrogram morphologies, and ECG features in two patients with heart failure and LBBB ECG. Methods Ventricular electrical activity was simulated using reaction-diffusion models with patient-specific anatomies. From the simulated action potentials, ECGs and cardiac electrograms were computed by solving the bidomain equation. Model parameters such as earliest activation sites, tissue conductivity, and densities of ionic currents were tuned to reproduce the measured signals. Results ECG morphology and activation order could be matched simultaneously. Local electrograms matched well at some sites, but overall the measured waveforms had deeper S waves than the simulated waveforms. Conclusion Tuning a reaction-diffusion model of the human heart to reproduce measured ECGs and electrograms is feasible and may provide insights in individual disease characteristics that cannot be obtained by other means.
Type de document :
Article dans une revue
Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, Oxford University Press, 2014, 16, pp.iv56-iv61. 〈10.1093/europace/euu257〉
Liste complète des métadonnées

Littérature citée [36 références]  Voir  Masquer  Télécharger
https://hal.inria.fr/hal-01080113
Contributeur : Mark Potse <>
Soumis le : mardi 4 novembre 2014 - 14:30:47
Dernière modification le : jeudi 11 janvier 2018 - 06:23:41
Document(s) archivé(s) le : jeudi 5 février 2015 - 11:00:34

Fichier

potse-trm13.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

INRIA | IMB

Citation

Mark Potse, Dorian Krause, Wilco Kroon, Romina Murzilli, Stefano Muzzarelli, et al.. Patient-specific modelling of cardiac electrophysiology in heart-failure patients. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, Oxford University Press, 2014, 16, pp.iv56-iv61. 〈10.1093/europace/euu257〉. 〈hal-01080113〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

323

Téléchargements de fichiers

155

Contact


archive-ouverte@inria.fr