Equilibria and stability analysis of a branched metabolic network with feedback inhibition

Frédéric Grognard 1 Yacine Chitour 2 Georges Bastin 3
1 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
2 Division Systèmes
L2S - Laboratoire des signaux et systèmes
Abstract : This paper deals with the analysis of a metabolic network with feedback inhibition. The considered system is an acyclic network of mono-molecular enzymatic reactions in which metabolites can act as feedback regulators on "preceding" enzymes of their own pathway, and in which one metabolite is the root of the whole network. We show, under mild assumptions, the uniqueness of the equilibrium. In the simplified case where inhibition only acts on the reactions having the root of the network as substrate, we show that the equilibrium is globally attractive. This requires that we impose conditions on the kinetic parameters of the metabolic reactions.
Type de document :
Article dans une revue
Networks and Heterogeneous Media, AIMS-American Institute of Mathematical Sciences, 2006, 1 (1), pp.219-239. 〈10.3934/nhm.2006.1.219〉
Liste complète des métadonnées

Littérature citée [5 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01090325
Contributeur : Jean-Luc Gouzé <>
Soumis le : mercredi 3 décembre 2014 - 13:08:12
Dernière modification le : jeudi 22 février 2018 - 01:20:47
Document(s) archivé(s) le : samedi 15 avril 2017 - 01:50:15

Fichier

nancy.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Frédéric Grognard, Yacine Chitour, Georges Bastin. Equilibria and stability analysis of a branched metabolic network with feedback inhibition. Networks and Heterogeneous Media, AIMS-American Institute of Mathematical Sciences, 2006, 1 (1), pp.219-239. 〈10.3934/nhm.2006.1.219〉. 〈hal-01090325〉

Partager

Métriques

Consultations de la notice

397

Téléchargements de fichiers

119