D. Thompson, J. Edelsberg, G. A. Colditz, A. P. Bird, and G. Oster, Lifetime health and economic consequences of obesity, Arch Intern Med, vol.159, pp.2177-2183, 1999.

O. Leal-vde and D. Mafra, Adipokines in obesity, Clin Chim Acta, vol.18, pp.87-94, 2013.

A. G. Dulloo and J. P. Montani, Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview, Obes Rev, vol.13, pp.1-5, 2012.

C. M. Carmean, R. N. Cohen, and M. J. Brady, Systemic regulation of adipose metabolism, Biochim Biophys Acta, vol.1842, issue.3, pp.424-454, 2014.

L. K. Meyer, T. P. Ciaraldi, R. R. Henry, A. C. Wittgrove, and S. A. Phillips, Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity, Adipocyte, vol.2, issue.4, pp.217-243, 2013.

Y. Zhang, J. L. Zitsman, J. Hou, I. Fennoy, and K. Guo, Fat cell size and adipokine expression in relation to gender, depot and metabolic risk factors in morbidly obese adolescents, Obesity, 2013.

S. P. Weisberg, D. Mccann, M. Desai, M. Rosenbaum, and R. L. Leibel, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest, vol.112, pp.1796-1808, 2003.

F. D. Demartinis and A. Francendese, Very small fat cell populations: mammalian occurrence and effect of age, J Lipid Res, vol.23, issue.8, pp.1107-1127, 1982.

J. W. Bailey, R. L. Barker, and R. E. Beauchene, Age-related changes in rat adipose tissue cellularity are altered by dietary restriction and exercise, J Nutr, vol.123, issue.1, pp.52-60, 1993.

T. Mclaughlin, A. Sherman, P. Tsao, O. Gonzalez, and G. Yee, Enhanced proportion of small adipose cells in insulinresistant vs insulin-sensitive obese individuals implicates impaired adipogenesis, Diabetologia, vol.50, pp.1707-1715, 2007.

A. Hammarstedt, T. E. Graham, and B. B. Kahn, Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells, Diabetol Metab Syndr, vol.19, issue.1, p.42, 2012.

C. Farnier, S. Krief, M. Blache, F. Diot-dupuy, and G. Mory, Adipocytes functions are modulated by cell size change involvement of an integrin/ERK signaling pathway, Int J Obes Relat Metab Disord, vol.27, pp.1178-1186, 2003.

M. Jernås, J. Palming, K. Sjöholm, E. Jennische, and P. A. Svensson, Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression, FASEB J, vol.20, pp.832-839, 2006.

A. Veilleux, M. Caron-jobin, S. Noël, P. Y. Laberge, and A. Tchernof, Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women, Diabetes, vol.60, pp.1504-1511, 2011.

T. Skurk, C. Alberti-huber, C. Herder, and H. Hauner, Relationship between Adipocyte Size and Adipokine Expression and Secretion, J Clin Endocrinol Metab, vol.92, pp.1023-1033, 2006.

T. Mclaughlin, A. Deng, G. Yee, C. Lamendola, and G. Reaven, Inflammation in subcutaneous adipose tissue: relationship to adipose cell size, Diabetologia, vol.53, pp.369-377, 2010.

J. M. Stephens, The fat controller: adipocyte development, PLoS Biol, vol.10, issue.11, p.1001436, 2012.

N. Tentolouris, S. Liatis, and N. Katsilambros, Sympathetic system activity in obesity and metabolic syndrome, Ann N Y Acad Sci, vol.1083, pp.129-52, 2006.

M. P. Czech, M. Tencerova, D. J. Pedersen, and M. Aouadi, Insulin signalling mechanisms for triacylglycerol storage, Diabetologia, vol.56, issue.5, pp.949-64, 2013.

A. Géloën, A. J. Collet, G. Guay, and L. J. Bukowiecki, Insulin stimulates in vivo cell proliferation in white adipose tissue, Am J Physiol, vol.256, pp.190-196, 1989.

A. Géloën, P. E. Roy, and L. J. Bukowiecki, Regression of white adipose tissue in diabetic rats, Am J Physiol, vol.257, pp.547-553, 1989.

P. Patel and N. Abate, Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance, J Obes. Article ID, vol.489187, 2013.

M. Rodbell, Methods for the determination of adipose cell size in man and animals, J Lipid Res, vol.239, issue.1, pp.110-119, 1964.

H. A. Soula, J. H. Soulage, C. O. Géloën, and A. , Modelling adipocytes size distribution, J Theor Biol, vol.332, pp.89-95, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00850474

J. Jo, O. Gavrilova, S. Pack, W. Jou, and S. Mullen, Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth, PLoS Comput Biol, vol.5, issue.3, p.1000324, 2009.

R. B. Harris, Direct and indirect effects of leptin on adipocyte metabolism, Biochim Biophys Acta, vol.1842, issue.3, pp.414-437, 2014.

M. Spencer, A. Yao-borengasser, R. Unal, N. Rasouli, and C. M. Gurley, Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation, Am J Physiol Endocrinol Metab, vol.299, pp.1016-1027, 2010.

M. Pasarica, B. Gowronska-kozak, D. Burk, I. Remedios, and D. Hymel, Adipose tissue collagen VI in obesity, J Clin Endocrinol Metab, vol.94, pp.5155-5162, 2009.

B. M. Spiegelman and C. A. Ginty, Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes, Cell, vol.35, pp.657-666, 1983.

Q. A. Wang, C. Tao, R. K. Gupta, and P. E. Scherer, Tracking adipogenesis during white adipose tissue development, expansion and regeneration, Nat Med, vol.19, issue.10, pp.1338-1382, 2013.

A. T. Ali, W. E. Hochfeld, R. Myburgh, and M. S. Pepper, Adipocyte and adipogenesis, Eur J Cell Biol, vol.92, issue.6-7, pp.229-265, 2013.

J. B. Kim, H. M. Wright, M. Wright, and B. M. Spiegelman, ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand, Proc Natl Acad SciUSA, vol.95, pp.4333-4337, 1998.

J. B. Kim and B. M. Spiegelman, ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism, Genes Dev, vol.10, pp.1096-1107, 1996.

M. Foretz, C. Guichard, P. Ferre, and F. Foufelle, Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes, Proc Natl Acad Sci U S A, vol.96, pp.12737-12742, 1999.
URL : https://hal.archives-ouvertes.fr/hal-02350030

E. D. Rosen, C. H. Hsu, X. Wang, S. Sakai, and M. W. Freeman, C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway, Genes Dev, vol.1, issue.1, pp.22-28, 2002.

M. I. Lefterova, A. K. Haakonsson, M. A. Lazar, and S. Mandrup, PPARc and the global map of adipogenesis and beyond, Trends Endocrinol Metab, vol.25, issue.6, pp.293-302, 2014.

Y. D. Tchoukalova, S. B. Votruba, T. Tchkonia, N. Giorgadze, and J. L. Kirkland, Regional differences in cellular mechanisms of adipose tissue gain with overfeeding, Proc Natl Acad Sci U S A, vol.19, issue.42, pp.18226-18257, 2010.

V. A. Payne, W. S. Au, C. E. Lowe, S. M. Rahman, and J. E. Friedman, C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis, Biochem J, vol.425, pp.215-238, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00479233

P. G. Cammisotto and L. J. Bukowiecki, Mechanisms of leptin secretion from white adipocytes, Am J Physiol Cell Physiol, vol.283, pp.244-50, 2002.

Y. Wang, Y. Ali, C. Y. Lim, W. Hong, and Z. P. Pang, Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation, Biochem J, vol.458, pp.491-499, 2014.

T. Khan, E. S. Muise, P. Iyengar, Z. V. Wang, and M. Chandalia, Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI, Mol Cell Biol, vol.29, pp.1575-91, 2009.