Skip to Main content Skip to Navigation
New interface
Conference papers

Extracting a biomarker for the mean cross-sectional area from the ODF

Rutger H.J. Fick 1 Gonzalo Sanguinetti 1 Rachid Deriche 1 
1 ATHENA - Computational Imaging of the Central Nervous System
CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : Finding new biomarkers related to the microstructure of white matter (WM) is an active area of research in theMRI community [1]. As opposed to the usual MRI markers such as fractional anisotropy (FA), thesebiomarkers provide a closer insight on the tissue structure. We introduce a new microstructure basedbiomarker that is related to the axon diameter distribution (ADD) and can be obtained with a q-space imaging[2] technique like DSI [3] or MAP [4]. This feature is related with the nature and purpose of WM paths in bothnormal and pathological conditions [5], and is obtained from the Orientation Distribution Function (ODF) [6] astwice its maximum value. We show that this value is related with the mean cross-sectional area (MCSA) of anensemble of parallel axons. The same geometric feature was proposed in [4] as a scalar index ofmicrostructure, but was not related to the ODF. In this work we give the formal relation between thismicrostructure feature and the ODF, and validate it using state-of-the-art numerical simulations.
Document type :
Conference papers
Complete list of metadata

Cited literature [9 references]  Display  Hide  Download
Contributor : Rutger Fick Connect in order to contact the contributor
Submitted on : Monday, December 15, 2014 - 11:40:07 AM
Last modification on : Saturday, June 25, 2022 - 11:15:30 PM
Long-term archiving on: : Monday, March 16, 2015 - 11:10:50 AM


Files produced by the author(s)


  • HAL Id : hal-01095197, version 1



Rutger H.J. Fick, Gonzalo Sanguinetti, Rachid Deriche. Extracting a biomarker for the mean cross-sectional area from the ODF. Human Brain Mapping, Jul 2014, Hamburg, Germany. ⟨hal-01095197⟩



Record views


Files downloads