Extracting a biomarker for the mean cross-sectional area from the ODF

Abstract : Finding new biomarkers related to the microstructure of white matter (WM) is an active area of research in theMRI community [1]. As opposed to the usual MRI markers such as fractional anisotropy (FA), thesebiomarkers provide a closer insight on the tissue structure. We introduce a new microstructure basedbiomarker that is related to the axon diameter distribution (ADD) and can be obtained with a q-space imaging[2] technique like DSI [3] or MAP [4]. This feature is related with the nature and purpose of WM paths in bothnormal and pathological conditions [5], and is obtained from the Orientation Distribution Function (ODF) [6] astwice its maximum value. We show that this value is related with the mean cross-sectional area (MCSA) of anensemble of parallel axons. The same geometric feature was proposed in [4] as a scalar index ofmicrostructure, but was not related to the ODF. In this work we give the formal relation between thismicrostructure feature and the ODF, and validate it using state-of-the-art numerical simulations.
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Communication dans un congrès
Human Brain Mapping, Jul 2014, Hamburg, Germany
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Contributeur : Rutger Fick <>
Soumis le : lundi 15 décembre 2014 - 11:40:07
Dernière modification le : jeudi 11 janvier 2018 - 16:41:49
Document(s) archivé(s) le : lundi 16 mars 2015 - 11:10:50


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  • HAL Id : hal-01095197, version 1



Rutger Fick, Gonzalo Sanguinetti, Rachid Deriche. Extracting a biomarker for the mean cross-sectional area from the ODF. Human Brain Mapping, Jul 2014, Hamburg, Germany. 〈hal-01095197〉



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