Physiologically Informed Bayesian Analysis of ASL fMRI Data

Abstract : Arterial Spin Labelling (ASL) functional Magnetic Resonance Imaging (fMRI) data provides a quantitative measure of blood perfusion, that can be correlated to neuronal activation. In contrast to BOLD measure, it is a direct measure of cerebral blood flow. However, ASL data has a lower SNR and resolution so that the recovery of the perfusion response of interest suffers from the contamination by a stronger hemodynamic component in the ASL signal. In this work we consider a model of both hemodynamic and perfusion components within the ASL signal. A physiological link between these two components is analyzed and used for a more accurate estimation of the perfusion response function in particular in the usual ASL low SNR conditions.
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Aina Frau-Pascual, Thomas Vincent, Jennifer Sloboda, Philippe Ciuciu, Florence Forbes. Physiologically Informed Bayesian Analysis of ASL fMRI Data. BAMBI 2014 - First International Workshop on Bayesian and grAphical Models for Biomedical Imaging, Sep 2014, Boston, United States. pp.37 - 48, ⟨10.1007/978-3-319-12289-2_4⟩. ⟨hal-01100266⟩

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