EEG-NIRS based assessment of neurovascular coupling during anodal transcranial direct current stimulation - a stroke case series

Abstract : Objective: A method for electroencephalography (EEG) - near-infrared spectroscopy (NIRS) based assessment of neurovascular coupling (NVC) during anodal transcranial direct current stimulation (tDCS). Methods: Anodal tDCS modulates cortical neural activity leading to a hemodynamic response, which was used to identify impaired NVC functionality. In this study, the hemodynamic response was estimated with NIRS. NIRS recorded changes in oxy-hemoglobin ( ) and deoxy-hemoglobin ( ) concentrations during anodal tDCS-induced activation of the cortical region located under the electrode and in-between the light sources and detectors. Anodal tDCS-induced alterations in the underlying neuronal current generators were also captured with EEG. Then, a method for the assessment of NVC underlying the site of anodal tDCS was proposed that leverages the Hilbert-Huang Transform. Results: The case series including four chronic (>6 months) ischemic stroke survivors (3 males, 1 female from age 31 to 76) showed non-stationary effects of anodal tDCS on EEG that correlated with the response. Here, the initial dip in at the beginning of anodal tDCS corresponded with an increase in the log-transformed mean-power of EEG within 0.5Hz-11.25Hz frequency band. The cross-correlation coefficient changed signs but was comparable across subjects during and after anodal tDCS. The log-transformed mean-power of EEG lagged response during tDCS but then led post-tDCS. Conclusion: This case series demonstrated changes in the degree of neurovascular coupling to a 0.526A/m2 square-pulse (0-30sec) of anodal tDCS. The initial dip in needs to be carefully investigated in a larger cohort, for example in patients with small vessel disease.
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Anirban Dutta, Athira Jacob, Shubhajit Roy Chowdhury, Abhijit Das, Michael Nitsche. EEG-NIRS based assessment of neurovascular coupling during anodal transcranial direct current stimulation - a stroke case series. Journal of Medical Systems, Springer Verlag (Germany), 2015, 39 (4), pp.205-226. ⟨10.1007/s10916-015-0205-7⟩. ⟨hal-01100750⟩

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