Pathogenetic mechanisms of hepatic encephalopathy, Gut, vol.57, issue.8, pp.1156-1165, 2008. ,
DOI : 10.1136/gut.2007.122176
Hepatocyte Heterogeneity in Glutamine and Ammonia Metabolism and the Role of an Intercellular Glutamine Cycle during Ureogenesis in Perfused Rat Liver, European Journal of Biochemistry, vol.37, issue.2, pp.269-275, 1983. ,
DOI : 10.1016/0003-9861(65)90208-0
Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture, EMBO J, vol.2, pp.567-570, 1983. ,
Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat, Hepatology, vol.279, issue.5, pp.1065-1073, 2005. ,
DOI : 10.1002/hep.20662
Hepatocyte heterogeneity in ammonia metabolism: Impairment of glutamine synthesis in CCl4 induced liver cell necrosis with no effect on urea synthesis, Chemico-Biological Interactions, vol.48, issue.2, pp.191-194, 1984. ,
DOI : 10.1016/0009-2797(84)90120-0
Hepatocyte heterogeneity in the metabolism of amino acids and ammonia, Enzyme, vol.46, pp.72-93, 1992. ,
Hepatocellular expression of glutamine synthetase: An indicator of morphogen actions as master regulators of zonation in adult liver, Progress in Histochemistry and Cytochemistry, vol.41, issue.4, pp.201-266, 2007. ,
DOI : 10.1016/j.proghi.2006.12.001
Hepatic glutaminase mRNA is confined to part of the urea cycle domain in the adult rodent liver lobule, FEBS Letters, vol.95, issue.1, pp.76-80, 1994. ,
DOI : 10.1016/0014-5793(94)01230-X
Glutamine metabolism and signaling in the liver, Frontiers in Bioscience, vol.12, issue.1, pp.371-391, 2007. ,
DOI : 10.2741/2070
Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease, European Journal of Clinical Investigation, vol.3, issue.5, pp.535-542, 1988. ,
DOI : 10.1002/hep.1840060412
The pathophysiology of brain edema in acute liver failure, Neurochemistry International, vol.47, issue.1-2, pp.71-77, 2005. ,
DOI : 10.1016/j.neuint.2005.04.009
THE SIMULATION OF THE UREA CYCLE: CORRELATION OF EFFECTS DUE TO INBORN ERRORS IN THE CATALYTIC PROPERTIES OF THE ENZYMES WITH CLINICAL-BIOCHEMICAL OBSERVATIONS, Australian Journal of Experimental Biology and Medical Science, vol.55, issue.3, pp.309-326, 1977. ,
DOI : 10.1038/icb.1977.26
Control of acid-base and ammonia homeostasis by the liver, WSEAS Transact Biol Biomed, vol.1, pp.294-297, 2004. ,
A cell-based simulation software for multi-cellular systems, Bioinformatics, vol.26, issue.20, pp.2641-2642, 2010. ,
DOI : 10.1093/bioinformatics/btq437
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration, Proceedings of the National Academy of Sciences, vol.107, issue.23, pp.10371-10376, 2010. ,
DOI : 10.1073/pnas.0909374107
The virtual liver: a multidisciplinary, multilevel challenge for systems biology, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol.10, issue.3, pp.221-235, 2012. ,
DOI : 10.1002/wsbm.1158
Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion?technique and applications, Z Gastroenterol, vol.35, pp.221-226, 1997. ,
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver, Proceedings of the National Academy of Sciences, vol.104, issue.8, pp.3003-3008, 2007. ,
DOI : 10.1073/pnas.0611434104
Control of the levels of free amino acids in plasma by the liver, Biochem Z, vol.343, pp.407-415, 1965. ,
Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.759, issue.3, pp.296-302, 1983. ,
DOI : 10.1016/0304-4165(83)90327-6
Partial purification and properties of rat liver glutaminase, Biochemical Journal, vol.220, issue.2, pp.583-590, 1984. ,
DOI : 10.1042/bj2200583
Glutamine synthetase from rat liver. Purification, properties, and preparation of specific antisera, J Biol Chem, vol.253, pp.6111-6118, 1978. ,
A hybrid multiscale model of solid tumor growth and invasion: evolution and the microenvironment Single-Cell-Based Models in Biology and Medicine, Birkh? auser, vol.2007, pp.3-28 ,
Center-based single-cell models: an approach to multi-cellular organization based on a conceptual analogy to colloidal particles Single-Cell-Based Models in Biology and Medicine Birkh? auser, pp.171-196 ,
: monolayers and spheroids, Physical Biology, vol.2, issue.3, pp.133-147, 2005. ,
DOI : 10.1088/1478-3975/2/3/001
Liver Microvascular Architecture: An Insight into the Pathophysiology of Portal Hypertension, Seminars in Liver Disease, vol.19, issue.04, pp.359-382, 1999. ,
DOI : 10.1055/s-2007-1007126
Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo, Am J Physiol, vol.238, pp.553-560, 1980. ,
Interorgan ammonia trafficking in liver disease, Metabolic Brain Disease, vol.2, issue.4, pp.169-181, 2009. ,
DOI : 10.1007/s11011-008-9122-5