Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and Functional Connectivity between Cortical Areas

Kristin K. Sellers 1 Davis V. Bennett 1 Axel Hutt 2 James Williams 1 Flavio Frohlich 1, *
* Corresponding author
2 NEUROSYS - Analysis and modeling of neural systems by a system neuroscience approach
Inria Nancy - Grand Est, LORIA - AIS - Department of Complex Systems, Artificial Intelligence & Robotics
Abstract : During general anesthesia, global brain activity and behavioral state are profoundly altered. Yet, it remains mostly unknown how anesthetics alter sensory processing across cortical layers and modulate functional cortico-cortical connectivity. To address this gap in knowledge of the micro- and mesoscale effects of anesthetics on sensory processing in the cortical microcircuit, we recorded multiunit activity (MUA) and local field potential (LFP) in awake and anesthetized ferrets (Mustela putoris furo) during sensory stimulation. In order to understand how anesthetics alter sensory processing in a primary sensory area and the representation of sensory input in higher-order association areas, we studied the local sensory responses and long-range functional connectivity of primary visual cortex (V1) and prefrontal cortex (PFC). Isoflurane combined with xylazine provided general anesthesia for all anesthetized recordings. We found that anesthetics altered the duration of sensory-evoked responses, disrupted the response dynamics across cortical layers, suppressed both multimodal interactions in V1 and sensory responses in PFC, and reduced functional cortico-cortical connectivity between V1 and PFC. Together, the present findings demonstrate altered sensory responses and impaired functional network connectivity during anesthesia at the level of MUA and LFP across cortical layers.
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Kristin K. Sellers, Davis V. Bennett, Axel Hutt, James Williams, Flavio Frohlich. Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and Functional Connectivity between Cortical Areas. Journal of Neurophysiology, American Physiological Society, 2015, pp.64. ⟨10.1152/jn.00923.2014⟩. ⟨hal-01140184⟩

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