A variable reference trajectory for model-free glycemia regulation

Abstract : The control design of an artificial pancreas, a hot research topic in diabetology, is tackled via the newly introduced model-free control and its corresponding "intelligent" proportional controller, which were already quite successful in many concrete and diverse situations. It results in an insulin injection for type 1 diabetes which displays via constant references a good nocturnal/fasting response, but unfortunately a poor postprandial behavior due to long hyperglycemia. When a variable reference is introduced, that switches between a constant one, when glycemia is more or less normal or moderate, and an exponential decay reference path, when a high glycemia rate indicates a meal intake, the results in silico, which employ real clinical data, become excellent. We obtain a bolus-shaped insulin injection rate during postprandial phases. The hyperglycemic peaks are therefore lowered a lot.
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Taghreed Mohammad Ridha, Claude Moog, Emmanuel Delaleau, Michel Fliess, Cédric Join. A variable reference trajectory for model-free glycemia regulation. SIAM Conference on Control & its Applications (SIAM CT15), Jul 2015, Paris, France. ⟨hal-01141268⟩

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