Accurate generation of a land cover map using hyperspectral data is an important application of remote sensing. Multiple classifier system (MCS) is an effective tool for hyperspec-tral image classification. However, most of the research in MCS addressed the problem of classifier combination, while the potential of selecting classifiers dynamically is least explored for hyper-spectral image classification. The goal of this paper is to assess the potential of dynamic classifier selection/dynamic ensemble selection (DCS/DES) for classification of hyperspectral images, which consists in selecting the best (subset of) optimal classifier(s) relative to each input pixel by exploiting the local information content of the image pixel. In order to have an accurate as well as com-putationally fast DCS/DES, we proposed a new DCS/DES framework based on extreme learning machine (ELM) regression and a new spectral–spatial classification model, which incorporates the spatial contextual information by using the Markov random field (MRF) with the proposed DES method. The proposed classification framework can be considered as a unified model to exploit the full spectral and spatial information. Classification experiments carried out on two different airborne hyperspectral images demonstrate that the proposed method yields a significant increase in the accuracy when compared to the state-of-the-art approaches.