From extraction of physiological features with dynamic µ-SPECT imaging to modelling of iodide biodistribution in stomach

Marine Breuilly 1 Kaouthar Chatti 2 Jacques Darcourt 2 Philippe Franken 2 Julien Guglielmi 2 Grégoire Malandain 3 Thierry Pourcher 2
1 ASCLEPIOS - Analysis and Simulation of Biomedical Images
CRISAM - Inria Sophia Antipolis - Méditerranée
2 TIRO - UMR E4320 - Transporteurs en Imagerie et Radiothérapie en Oncologie
CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/BIAM, CNRS - Centre National de la Recherche Scientifique, TIRO-MATOs - UMR E4320 : UMR E4320
3 MORPHEME - Morphologie et Images
CRISAM - Inria Sophia Antipolis - Méditerranée , IBV - Institut de Biologie Valrose : U1091, Laboratoire I3S - SIS - Signal, Images et Systèmes
Abstract : This study investigates the potential retention of iodide in the stomach, for a better understanding of the iodide biodistribution in the body and more precisely of its potential antiseptic role. To that end, we will study the uptake of the 99m Tc-pertechnetate (an iodide ana-log) within the murine stomach observed thanks to a SPECT camera. The temporal evolution of the uptake is analysed thanks to a dedicated multi-compartment model. The addressed challenges consist in 1) estimating the time-activity curves for the different compartments, and 2) identifying the model parameters. Real experiments on different subjects demonstrate a quite good coherence of the computed parameters, and the computed parameter values suggested that there is some iodide retention in the stomach wall.
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Marine Breuilly, Kaouthar Chatti, Jacques Darcourt, Philippe Franken, Julien Guglielmi, et al.. From extraction of physiological features with dynamic µ-SPECT imaging to modelling of iodide biodistribution in stomach. [Research Report] Inria Sophia Antipolis. 2015. ⟨hal-01186222v2⟩

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