From extraction of physiological features with dynamic µ-SPECT imaging to modelling of iodide biodistribution in stomach - Archive ouverte HAL Access content directly
Reports (Research Report) Year : 2015

From extraction of physiological features with dynamic µ-SPECT imaging to modelling of iodide biodistribution in stomach

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Abstract

This study investigates the potential retention of iodide in the stomach, for a better understanding of the iodide biodistribution in the body and more precisely of its potential antiseptic role. To that end, we will study the uptake of the 99m Tc-pertechnetate (an iodide ana-log) within the murine stomach observed thanks to a SPECT camera. The temporal evolution of the uptake is analysed thanks to a dedicated multi-compartment model. The addressed challenges consist in 1) estimating the time-activity curves for the different compartments, and 2) identifying the model parameters. Real experiments on different subjects demonstrate a quite good coherence of the computed parameters, and the computed parameter values suggested that there is some iodide retention in the stomach wall.
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Dates and versions

hal-01186222 , version 1 (24-08-2015)
hal-01186222 , version 2 (31-08-2015)

Identifiers

  • HAL Id : hal-01186222 , version 2

Cite

Marine Breuilly, Kaouthar Chatti, Jacques Darcourt, Philippe Franken, Julien Guglielmi, et al.. From extraction of physiological features with dynamic µ-SPECT imaging to modelling of iodide biodistribution in stomach. [Research Report] Inria Sophia Antipolis. 2015. ⟨hal-01186222v2⟩
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