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Enantiopure Peptide-Functionalized Metal-Organic Frameworks

Abstract : We present herein the first example of metal-organic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH2, In-MIL-68-NH2, and Zr-UiO-66-NH2 were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction.
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Submitted on : Friday, July 31, 2020 - 6:12:53 PM
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J. Bonnefoy, A. Legrand, E. A. Quadrelli, J. Canivet, D. Farrusseng. Enantiopure Peptide-Functionalized Metal-Organic Frameworks. Journal of the American Chemical Society, American Chemical Society, 2015, 137 (29), pp.9409-9416. ⟨10.1021/jacs.5b05327⟩. ⟨hal-01198957⟩



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