C. Study, We gratefully thank all members of the nursing staff of each participating ICU for their strong involvement and motivation in the study

H. Haut-levesque and C. Bordeaux, Service Anesthésie réanimation I (Dr Alexandre Ouattara), and Service Anesthésie Réanimation II Chirurgie digestive

A. and J. Verdier, Réanimation médico-chirurgicale (Dr Alexandre Avenel, Dr Roland Amathieu); Hôpital Saint-Camille

. Hôpital-louis-pasteur, L. Ch-de-chartres, and . Coudray, Réanimation polyvalente (Dr Olivier Gontier, CH de Châteauroux

C. Clinique-des-cèdres, Réanimation polyvalente (Dr Patrick Blanchet)

A. and R. Poincaré, Réanimation polyvalente (Dr Virginie Maxime, Dr Djillali Annane); CH départemental de Vendée, Dr Jean Reignier

. Hôpital-la-timone and . Chu-de-marseille, Service d'Anesthésie Réanimation 1 (Dr Emmanuel Cantais

H. Lapeyronie and . Chu-de-montpellier, Dr Jonathan Charbit, Dr Karim Lakhal); Hôpital Saint-Eloi, Dr Gérald Chanques

H. Laënnec, C. Nantes, A. , C. Bichat, and A. Chu-pitié-salpétriêre, Nice (Dr Carole Ichai, Dr Jean-Christophe Orban), Dr Bruno Mourvillier Dr Alexandre Duguet, pp.Réanimation médico-chirurgicale

. Hôpital-rené-dubos and . Ch-de-pontoise, Dr Jack Richecoeur)

H. Foch, Dr Florent Perin- Dureau; Hôpital Font-Pré

H. Purpan and C. Toulouse, Réanimation polyvalente (Dr Béatrice Riu-Poulenc, Dr Michèle Genestal

H. Rangueil and . Chu-de-toulouse, Réanimation médicale (Dr Pierre Cougot, Dr Hélène Gonzalez

K. Dungan, S. Braithwaite, and J. Preiser, Stress hyperglycaemia, The Lancet, vol.373, issue.9677, pp.1798-807, 2009.
DOI : 10.1016/S0140-6736(09)60553-5

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144755

D. Lena, P. Kalfon, J. Preiser, and C. Ichai, Glycemic Control in the Intensive Care Unit and during the Postoperative Period, Anesthesiology, vol.114, issue.2, pp.438-482, 2011.
DOI : 10.1097/ALN.0b013e3182078843

G. Van-den-berghe, P. Wouters, F. Weekers, C. Verwaest, F. Bruyninckx et al., Intensive Insulin Therapy in Critically Ill Patients, New England Journal of Medicine, vol.345, issue.19, pp.1359-67, 2001.
DOI : 10.1056/NEJMoa011300

G. Van-den-berghe, A. Wilmer, G. Hermans, W. Meersseman, P. Wouters et al., Intensive Insulin Therapy in the Medical ICU, New England Journal of Medicine, vol.354, issue.5, pp.449-61, 2006.
DOI : 10.1056/NEJMoa052521

F. Brunkhorst, C. Engel, F. Bloos, A. Meier-hellmann, M. Ragaller et al., Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis, New England Journal of Medicine, vol.358, issue.2, pp.125-164, 2008.
DOI : 10.1056/NEJMoa070716

J. Preiser, P. Devos, S. Ruiz-santana, C. Melot, D. Annane et al., A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study, Intensive Care Medicine, vol.301, issue.180, pp.1738-1786, 2009.
DOI : 10.1007/s00134-009-1585-2

URL : https://hal.archives-ouvertes.fr/inserm-00422458

P. Kalfon, B. Giraudeau, C. Ichai, A. Guerrini, N. Brechot et al., Tight computerized versus conventional glucose control in the ICU: a randomized controlled trial, Intensive Care Medicine, vol.39, issue.2, pp.171-80, 2014.
DOI : 10.1007/s00134-013-3189-0

N. The and . Investigators, Intensive versus conventional glucose control in critically ill patients, N Engl J Med, vol.360, pp.1283-97, 2009.

R. Mccoy, N. Shah, H. Van-houten, R. Wermers, J. Ziegenfuss et al., Increased Mortality of Patients With Diabetes Reporting Severe Hypoglycemia, Diabetes Care, vol.35, issue.9, pp.1897-901, 2012.
DOI : 10.2337/dc11-2054

H. Gerstein, M. Miller, R. Byington, G. Jr, D. Bigger et al., Action to control cardiovascular risk in diabetes study group: effects of intensive glucose lowering in type 2 diabetes, N Engl J Med, vol.358, pp.2545-59, 2008.

N. The and . Investigators, Hypoglycemia and risk of death in critically ill patients, N Engl J Med, vol.367, pp.1108-1126, 2012.

G. Meyfroidt, D. Keenan, X. Wang, P. Wouters, J. Veldhuis et al., Dynamic characteristics of blood glucose time series during the course of critical illness: Effects of intensive insulin therapy and relative association with mortality*, Critical Care Medicine, vol.38, issue.4, pp.1021-1030, 2010.
DOI : 10.1097/CCM.0b013e3181cf710e

J. Krinsley, M. Schultz, P. Spronk, R. Harmsen, H. Van-braam et al., Mild hypoglycemia is independently associated with increased mortality in the critically ill, Critical Care, vol.15, issue.4, p.173, 2011.
DOI : 10.1186/cc9369

M. Egi, R. Bellomo, E. Stachowski, C. French, G. Hart et al., Hypoglycemia and Outcome in Critically Ill Patients, Mayo Clinic Proceedings, vol.85, issue.3, pp.217-241, 2010.
DOI : 10.4065/mcp.2009.0394

J. Hermanides, T. Vriesendorp, R. Bosman, D. Zandstra, J. Hoekstra et al., Glucose variability is associated with intensive care unit mortality*, Critical Care Medicine, vol.38, issue.3, pp.838-880, 2010.
DOI : 10.1097/CCM.0b013e3181cc4be9

S. Finfer, Hypoglycemia in critically ill adults - association yes, causation not proven, Critical Care, vol.15, issue.6, p.1012, 2011.
DOI : 10.1172/JCI30077

M. Cepeda, R. Boston, J. Farrar, and B. Strom, Comparison of Logistic Regression versus Propensity Score When the Number of Events Is Low and There Are Multiple Confounders, American Journal of Epidemiology, vol.158, issue.3, pp.280-287, 2003.
DOI : 10.1093/aje/kwg115

I. Mackenzie, T. Whitehouse, and P. Nightingale, The metrics of glycaemic control in critical care, Intensive Care Medicine, vol.35, issue.3, pp.435-478, 2011.
DOI : 10.1007/s00134-010-2103-2

R. Cinotti, C. Ichai, J. Orban, P. Kalfon, F. Feuillet et al., Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study, Critical Care, vol.188, issue.5, p.498, 2014.
DOI : 10.1186/s13054-014-0498-9

URL : https://hal.archives-ouvertes.fr/hal-01313106

L. Gall, J. Lemeshow, S. Saulnier, and F. , A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study, JAMA: The Journal of the American Medical Association, vol.270, issue.24, pp.2957-63, 1993.
DOI : 10.1001/jama.1993.03510240069035

W. Mccabe and G. Jackson, Gram-Negative Bacteremia, Archives of Internal Medicine, vol.110, issue.6, pp.847-81, 1962.
DOI : 10.1001/archinte.1962.03620240029006

J. Vincent, R. Moreno, J. Takala, S. Willatts, D. Mendonça et al., The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure, Intensive Care Medicine, vol.21, issue.7, pp.707-717, 1996.
DOI : 10.1007/BF01709751

G. Rubenfeld, D. Angus, M. Pinsky, J. Curtis, C. Jr et al., Outcomes Research in Critical Care, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.1, pp.358-67, 1999.
DOI : 10.1164/ajrccm.160.1.9807118

P. Austin, An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies, Multivariate Behavioral Research, vol.110, issue.3, pp.399-424, 2011.
DOI : 10.1016/j.drugalcdep.2009.03.018

P. Austin, Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies, Pharmaceutical Statistics, vol.29, issue.1, pp.150-61, 2011.
DOI : 10.1002/pst.433

J. Krinsley, M. Egi, A. Kiss, A. Devendra, P. Schuetz et al., Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study, Critical Care, vol.17, issue.2, p.37, 2013.
DOI : 10.1161/01.ATV.0000239488.05069.03

T. Vriesendorp, S. Van-santen, J. Devries, E. De-jonge, F. Rosendaal et al., Predisposing factors for hypoglycemia in the intensive care unit*, Critical Care Medicine, vol.34, issue.1, pp.96-101, 2006.
DOI : 10.1097/01.CCM.0000194536.89694.06

E. Gayat, R. Piracchio, M. Resche-rigon, A. Mebazaa, J. Mary et al., Propensity scores in intensive care and anaesthesiology literature: a systematic review, Intensive Care Medicine, vol.24, issue.12, pp.1993-2003, 2010.
DOI : 10.1007/s00134-010-1991-5

J. Krinsley and A. Grover, Severe hypoglycemia in critically ill patients: Risk factors and outcomes*, Critical Care Medicine, vol.35, issue.10, pp.2262-2269, 2007.
DOI : 10.1097/01.CCM.0000282073.98414.4B

C. Huang, Y. Wu, A. Hsieh, Y. Hung, W. Chen et al., Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality, Critical Care, vol.17, issue.1, p.22, 2013.
DOI : 10.1007/s00259-011-1994-7

G. Van-den-berghe, How does blood glucose control with insulin save lives in intensive care?, Journal of Clinical Investigation, vol.114, issue.9, pp.1187-95, 2004.
DOI : 10.1172/JCI23506

S. Goodman, Toward Evidence-Based Medical Statistics. 1: The P Value Fallacy, Annals of Internal Medicine, vol.130, issue.12, pp.995-1004, 1999.
DOI : 10.7326/0003-4819-130-12-199906150-00008

A. Hill, The environment and disease: association or causation?, Journal of the Royal Society of Medicine, vol.88, issue.1, pp.295-300, 1965.
DOI : 10.1177/0141076814562718

M. Kosiborod, S. Inzucchi, A. Goyal, H. Krumholz, F. Masoudi et al., Relationship Between Spontaneous and Iatrogenic Hypoglycemia and Mortality in Patients Hospitalized With Acute Myocardial Infarction, JAMA, vol.301, issue.15, pp.1556-64, 2009.
DOI : 10.1001/jama.2009.496

J. Chase, G. Shaw, L. Compte, A. Lonergan, T. Willacy et al., Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change, Critical Care, vol.12, issue.2, p.49, 2008.
DOI : 10.1186/cc6868

M. Bekaert, J. Timsit, S. Vansteelandt, P. Depuydt, A. Vésin et al., Attributable Mortality of Ventilator-Associated Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.184, issue.10
DOI : 10.1164/rccm.201105-0867OC

URL : https://hal.archives-ouvertes.fr/hal-00841199

C. Ichai and J. Preiser, International recommendations for glucose control in adult non diabetic critically ill patients, Crit Care, vol.14, p.166, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00628493

M. Plummer, R. Bellomo, C. Cousins, C. Anninck, K. Sundararajan et al., Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality, Intensive Care Medicine, vol.12, issue.7, pp.973-80, 2014.
DOI : 10.1007/s00134-014-3287-7

D. Macrea, R. Grieve, E. Allen, Z. Sadique, K. Morris et al., A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care, New England Journal of Medicine, vol.370, issue.2, pp.107-125, 2014.
DOI : 10.1056/NEJMoa1302564