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Qualitative modeling and simulation of bacterial regulatory networks

Hidde de Jong 1 
1 IBIS - Modeling, simulation, measurement, and control of bacterial regulatory networks
LAPM - Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble], Inria Grenoble - Rhône-Alpes, Institut Jean Roget
Abstract : The adaptation of microorganisms to their environment is controlled at the molecular level by large and complex networks of biochemical reactions involving genes, RNAs, proteins, metabolites, and small signalling molecules. In theory, it is possible to write down mathematical models of these networks, and study these by means of classical analysis and simulation tools. In practice, this is not easy to achieve though, as quantitative data on kinetic parameters are usually absent for most systems of biological interest. Moreover, the models consist of a large number of variables, are strongly nonlinear and include different time-scales, which make them difficult to handle both mathematically and computationally.
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Hidde de Jong. Qualitative modeling and simulation of bacterial regulatory networks. A. Uhrmacher; M. Heiner. Proceedings of 6th International Conference on Computational Methods in Systems Biology (CMSB 2008), 5307, Springer-Verlag, pp.1, 2008, Lecture Notes in Bioinformatics, ⟨10.1007/978-3-540-88562-7⟩. ⟨hal-01217994⟩



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