Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?

Paola Caroppo 1 Marie-Odile Habert 2 Stanley Durrleman 3 Aurélie Funkiewiez 4 Vincent Perlbarg 5 Valérie Hahn 6 Hugo Bertin 7, 8 Malo Gaubert 9 Alexandre Routier 3 Didier Hannequin 10 Vincent Deramecourt 11 Florence Pasquier 11 Sophie Rivaud-Pechoux 12 Martine Vercelletto 13 Geoffrey Edouart 6 Romain Valabregue 14 Pascal Lejeune 6 Mira Didic 6 Jean-Christophe Corvol 14 Habib Benali 2 Stéphane Lehéricy 14 Bruno Dubois 6 Olivier Colliot 3 Alexis Brice 14 Isabelle Le Ber 1, 15
Abstract : The preclinical stage of frontotemporal lobar degeneration (FTLD) is not well characterized. We conducted a brain metabolism (FDG-PET) and structural (cortical thickness) study to detect early changes in asymptomatic GRN mutation carriers (aGRN+) that were evaluated longitudinally over a 20-month period. At baseline, a left lateral temporal lobe hypometabolism was present in aGRN+ without any structural changes. Importantly, this is the first longitudinal study and, across time, the metabolism more rapidly decreased in aGRN+ in lateral temporal and frontal regions. The main structural change observed in the longitudinal study was a reduction of cortical thickness in the left lateral temporal lobe in carriers. A limit of this study is the relatively small sample (n = 16); nevertheless, it provides important results. First, it evidences that the pathological processes develop a long time before clinical onset, and that early neuroimaging changes might be detected approximately 20 years before the clinical onset of disease. Second, it suggests that metabolic changes are detectable before structural modifications and cognitive deficits. Third, both the baseline and longitudinal studies provide converging results implicating lateral temporal lobe as early involved in GRN disease. Finally, our study demonstrates that structural and metabolic changes could represent possible biomarkers to monitor the progression of disease in the presymptomatic stage toward clinical onset.
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Paola Caroppo, Marie-Odile Habert, Stanley Durrleman, Aurélie Funkiewiez, Vincent Perlbarg, et al.. Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?. Journal of Alzheimer's Disease, IOS Press, 2015, 47 (3), pp.751-9. ⟨10.3233/JAD-150270⟩. ⟨hal-01220380⟩

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