Towards a better understanding of the within-host dynamics to PRRSv: insights from modelling approach

Abstract : PRRSv is responsible for significant worldwide production losses and its control is a major challenge for the swine industry. Vaccination, the main control measure, does not allow to eradicate the infection and only confers a partial protection to the host. This lack of efficiency is mainly due to the strong variability in PRRSv strain virulence, which induces highly variable within-host dynamics. Consequently, there is a real need to better understand the interactions between the virus and the immune response in order to improve PRRSv control. To tackle this issue, a dynamic and deterministic modelling approach was chosen. We developed an original immunological model consisting in an integrative representation of the within-host dynamics. It describes the immune mechanisms at the between-cell scale, including the innate response, the activation and orientation of the adaptive response and their complex regulations by the major cytokines. By the definition of parameter sets based on published experimental and modelling studies, this approach allowed us to explore various scenarios in terms of host susceptibility, strain virulence, as well as dose and duration of viral exposure. Our first results show that similar infection durations associated with contrasted immune dynamics can be explained by the consideration of the immune mechanisms affected by the strain virulence. They provide new insights to explain apparent inconsistencies between experimental data. We then showed that the exposure, whose effect is often neglected, has an impact on the within-host dynamics, which varies depending on the virulence level. Finally, the within-host dynamics induced by the infection of a vaccinated pig is currently under exploration, opening up promising leads to improve vaccine efficiency. All these results provide new insights to guide further experimental and modelling approaches and they offer promising prospects to improve PRRSv control at the herd level by an immuno-epidemiological modelling approach.
Type de document :
Communication dans un congrès
International Porcine Reproductive And Respiratory Syndrome Congress, Jun 2015, Gand, Belgium
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https://hal.inria.fr/hal-01237154
Contributeur : Jean-Luc Gouzé <>
Soumis le : mercredi 2 décembre 2015 - 18:13:14
Dernière modification le : mardi 29 mai 2018 - 12:50:54

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  • HAL Id : hal-01237154, version 1

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Natacha Go, Catherine Belloc, Caroline Bidot, Suzanne Touzeau. Towards a better understanding of the within-host dynamics to PRRSv: insights from modelling approach. International Porcine Reproductive And Respiratory Syndrome Congress, Jun 2015, Gand, Belgium. 〈hal-01237154〉

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