Aerosols in Healthy and Emphysematous In Silico Pulmonary Acinar Rat Models

Jessica M. Oakes 1 Philipp Hofemeier 2 Irene Vignon-Clementel 1 Josué Sznitman 2
1 REO - Numerical simulation of biological flows
LJLL - Laboratoire Jacques-Louis Lions, UPMC - Université Pierre et Marie Curie - Paris 6, Inria de Paris
Abstract : There has been relatively little attention given on predicting particle deposition in the respiratory zone of the diseased lungs despite the high prevalence of chronic obstructive pulmonary disease (COPD). Increased alveolar volume and deterioration of alveolar septum, characteristic of emphysema, may alter the amount and location of particle deposition compared to healthy lungs, which is particularly important for toxic or therapeutic aerosols. In an attempt to shed new light on aerosol transport and deposition in emphysematous lungs, we performed numerical simulations in models of healthy and emphysematous acini motivated by recent experimental lobar-level data in rats~\citep{OakesEmp}. Compared to healthy acinar structures, models of emphysematous subacini were created by removing inter-septal alveolar walls and enhancing the alveolar volume in either a homogeneous or heterogeneous fashion. Flow waveforms and particle properties were implemented to match the experimental data. The occurrence of flow separation and recirculation within alveolar cavities was found in proximal generations of the healthy zones, in contrast to the radial-like airflows observed in the diseased regions. In agreement with experimental data, simulations point to particle deposition concentrations that are more heterogeneously distributed in the diseased models compared with the healthy one. Yet, simulations predicted less deposition in the emphysematous models in contrast to some experimental studies, a likely consequence due to the shallower penetration depths and modified flow topologies in disease compared to health. These spatial-temporal particle transport simulations provide new insight on deposition in the emphysematous acini and shed light on experimental observations.
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Article dans une revue
Journal of Biomechanics, Elsevier, 2016, 49 (11), pp.2213-2220. 〈10.1016/j.jbiomech.2015.11.026〉
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Contributeur : Irene Vignon-Clementel <>
Soumis le : mardi 15 décembre 2015 - 18:03:47
Dernière modification le : jeudi 26 avril 2018 - 10:28:34
Document(s) archivé(s) le : samedi 29 avril 2017 - 15:43:11

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Jessica M. Oakes, Philipp Hofemeier, Irene Vignon-Clementel, Josué Sznitman. Aerosols in Healthy and Emphysematous In Silico Pulmonary Acinar Rat Models. Journal of Biomechanics, Elsevier, 2016, 49 (11), pp.2213-2220. 〈10.1016/j.jbiomech.2015.11.026〉. 〈hal-01244458〉

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