Logical modeling of the mammalian cell cycle

Abstract : Proper understanding of the behavior of complex biological regulatory networks requires the integration of heterogeneous data into predictive mathematical models. Logical modeling focuses on qualitative data and offers a flexible framework to delineate the main dynamical properties of such networks. However, formal analysis faces a combinatorial explosion as the number of regulatory components and interactions increases. Here, we show how model-checking techniques can be used to verify sophisticated dynamical properties resulting from model regulatory structure. We demonstrate the power of this approach through the updating of a model of the molecular network controlling mammalian cell cycle. We use model-checking to progressively refine this model in order to fit recent experimental observations. The resulting model accounts for the sequential activation of cyclins, the role of Skp2, and emphasizes a multifunctional role for the cell cycle inhibitor Rb.
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https://hal.inria.fr/hal-01246595
Contributor : Pauline Traynard <>
Submitted on : Friday, December 18, 2015 - 5:21:14 PM
Last modification on : Friday, May 25, 2018 - 12:02:07 PM
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Pauline Traynard, Adrien Fauré, François Fages, Denis Thieffry. Logical modeling of the mammalian cell cycle. 2015. ⟨hal-01246595⟩

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