Skip to Main content Skip to Navigation
New interface
Journal articles

The white matter query language: a novel approach for describing human white matter anatomy

Abstract : We have developed a novel method to describe human white matter anatomy using an approach that is both intuitive and simple to use, and which automatically extracts white matter tracts from diffusion MRI vol¬umes. Further, our method simplifies the quantification and statistical analysis of white matter tracts on large diffusion MRI databases. This work reflects the careful syntactical definition of major white matter fiber tracts in the human brain based on a neuroanatomist's expert knowledge. The framework is based on a novel query language with a near-to-English textual syntax. This query language makes it possible to construct a dictionary of anatomical definitions that describe white matter tracts. The definitions include adjacent gray and white matter regions, and rules for spatial relations. This novel method makes it possible to automatically label white matter anatomy across subjects. After describing this method, we provide an example of its implementation where we encode anatomical knowledge in human white matter for 10 association and 15 projection tracts per hemisphere, along with 7 commissural tracts. Importantly, this novel method is comparable in accuracy to manual labeling. Finally, we present results applying this method to create a white matter atlas from 77 healthy subjects, and we use this atlas in a small proof-of-concept study to detect changes in association tracts that characterize schizophrenia.
Complete list of metadata

Cited literature [71 references]  Display  Hide  Download
Contributor : Demian Wassermann Connect in order to contact the contributor
Submitted on : Thursday, December 24, 2015 - 10:46:49 AM
Last modification on : Friday, November 18, 2022 - 9:28:18 AM
Long-term archiving on: : Sunday, April 30, 2017 - 12:35:14 AM


Files produced by the author(s)






Demian Wassermann, Nikos Makris, Yogesh Rathi, Martha Shenton, Ron Kikinis, et al.. The white matter query language: a novel approach for describing human white matter anatomy. Brain Structure and Function, 2016, ⟨10.1007/s00429-015-1179-4⟩. ⟨hal-01247061⟩



Record views


Files downloads