Emergence of cytotoxic resistance in cancer cell populations: single-cell mechanisms and population-level consequences

Abstract : We formulate an individual-based model and a population model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
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Tommaso Lorenzi, Rebecca H. Chisholm, Alexander Lorz, Annette K Larsen, Luís Almeida, et al.. Emergence of cytotoxic resistance in cancer cell populations: single-cell mechanisms and population-level consequences. ICNAAM 2015 Session 70: "Mathematical models and methods to investigate heterogeneity in cell and cell population biology", Jean Clairambault, Sep 2015, Rhodes, Greece. ⟨hal-01249239⟩

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