Preface to Session 70 " Mathematical models and methods to investigate heterogeneity in cell and cell population biology ": Presentation of Session 70 in ICNAAM 2015, Rhodes

Loic Barbarroux 1, 2, 3 Jean Clairambault 4, 5, * Nick Cogan 6 Jan Elias 4, 5 Shalla Hanson 7 Marek Kimmel 8 Tommaso Lorenzi 4, 5
* Corresponding author
2 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
ICJ - Institut Camille Jordan [Villeurbanne], Inria Grenoble - Rhône-Alpes, CGPhiMC - Centre de génétique et de physiologie moléculaire et cellulaire
3 MMCS - Modélisation mathématique, calcul scientifique
ICJ - Institut Camille Jordan [Villeurbanne]
4 MAMBA - Modelling and Analysis for Medical and Biological Applications
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt
Abstract : This session investigates hot topics related to mathematical representations of cell and cell population dynamics in biology and medicine, in particular, but not only, with applications to cancer. Methods in mathematical modelling and analysis, and in statistical inference using single-cell and cell population data, should contribute to focus this session on heterogeneity in cell populations. Among other methods are proposed: a) Intracellular protein dynamics and gene regulatory networks using ordinary/partial/delay differential equations (ODEs, PDEs, DDEs); b) Representation of cell population dynamics using agent-based models (ABMs) and/or PDEs; c) Hybrid models and multiscale models to integrate single-cell dynamics into cell population behaviour; d) Structured cell population dynamics and asymptotic evolution w.r.t. relevant traits; e) Heterogeneity in cancer cell populations: origin, evolution, phylogeny and methods of reconstruction; f) Drug resistance as an evolutionary phenotype: predicting and overcoming it in therapeutics; g) Theoretical therapeutic optimisation of combined drug treatments in cancer cell populations and in populations of other organisms, such as bacteria.
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Loic Barbarroux, Jean Clairambault, Nick Cogan, Jan Elias, Shalla Hanson, et al.. Preface to Session 70 " Mathematical models and methods to investigate heterogeneity in cell and cell population biology ": Presentation of Session 70 in ICNAAM 2015, Rhodes. ICNAAM 2015 Session 70: "Mathematical models and methods to investigate heterogeneity in cell and cell population biology'', Organiser Session 70: Jean Clairambault, Sep 2015, Rhodes, Greece. ⟨hal-01249244⟩

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