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Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects

Claire Cury 1 Roberto Toro 2 Fanny Cohen 1 Clara Fischer 3 Amel Mhaya 1 Jorge Samper-González 1 Dominique Hasboun 4, 5, 1 Jean-François Mangin 2 Tobias Banaschewski 6 Arun L. W. Bokde 7 Uli Bromberg 8 Christian Buechel 8 Anna Cattrell 9 Patricia Conrod 9 Herta Flor 10 Juergen Gallinat 11 Hugh Garavan 12 Penny Gowland 13 Andreas Heinz 11 Bernd Ittermann 11 Hervé Lemaitre 14 Jean-Luc Martinot 14 Frauke Nees 6 Marie-Laure Paillère Martinot 14 Dimitri P. Orfanos 3 Tomas Paus 15 Luise Poustka 10 Michael N. Smolka 16 Henrik Walter 17, 11 Robert Whelan 18 Vincent Frouin 3 Gunter Schumann 9 Joan A. Glaunès 19 Olivier Colliot 1, 4, 5, 20 
Abstract : The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ2−test, p < 10−28). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
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Claire Cury, Roberto Toro, Fanny Cohen, Clara Fischer, Amel Mhaya, et al.. Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects. Frontiers in Neuroanatomy, 2015, 9, pp.160. ⟨10.3389/fnana.2015.00160⟩. ⟨hal-01251239⟩



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