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Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.

Charlotte Rosso 1, 2 David Rosenbaum Christine Pires 3 Corinne Cherfils Nabil Koujah Fouzi Mestari Emeline Gillet 4 Sophie Crozier 3 Mélika Sahli-Amor Yves Samson 5 Dominique Bonnefont-Rousselot 6 Randa Khani-Bittar
1 CENIR - Centre de Neuro-Imagerie de Recherche
2 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
3 Service des Urgences Cérébro-Vasculaires [Paris]
4 Department of Electronics and Vacuum Physik
5 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
6 CHU Pitié-Salpêtrière [AP-HP]
Abstract : The objectives of the study were to compare lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in a prospective cohort including both ischemic and hemorrhagic strokes at the hyperacute phase, and to investigate if these levels were associated with stroke severity. Lp-PLA2 mass and activity were measured during the first 6 hours of symptom onset before any therapeutic intervention. The Lp-PLA2 level was analyzed by comparing the mass and activities in ischemic strokes and spontaneous intracerebral hemorrhages (ICH). Correlations between Lp-PLA2 levels and clinical scores as well as stroke volumes were made. The temporal evolution of Lp-PLA2 during the first week was analyzed in ischemic stroke patients. Lp-PLA2 mass was higher in ICH than in ischemic stroke (P = .001). Lp-PLA2 activity at admission correlated with initial and follow-up stroke volume in ICH (P = .003 and P = .004, respectively) but not in ischemic stroke. None of the measurements correlated with clinical severity for either diagnosis. Lp-PLA2 mass decreased during the first week after the use of statins in ischemic stroke, whereas the activity remained stable. Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
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Journal articles
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https://hal.inria.fr/hal-01253339
Contributor : Olivier Colliot <>
Submitted on : Saturday, January 9, 2016 - 6:53:48 PM
Last modification on : Thursday, December 10, 2020 - 3:38:49 AM

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  • HAL Id : hal-01253339, version 1
  • PUBMED : 24513482

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CNRS | UPMC | ICM | SORBONNE-UNIVERSITE | SU-MEDECINE | POLITIQUES-PUBLIQUES

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Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, et al.. Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.. Journal of Stroke and Cerebrovascular Diseases, WB Saunders, 2014, 23 (4), pp.e277-82. ⟨hal-01253339⟩

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