Ensuring successful introduction of Wolbachia in natural populations of Aedes aegypti by means of feedback control

Abstract : The control of the spread of dengue fever by introduction of the intracellular parasitic bacterium Wolbachia in populations of the vector Aedes aegypti, is presently one of the most promising tools for eliminating dengue, in the absence of an efficient vaccine. The success of this operation requires locally careful planning to determine the adequate number of individuals carrying the Wolbachia parasite that need to be introduced into the natural population. The introduced mosquitoes are expected to eventually replace the Wolbachia-free population and guarantee permanent protection against the transmission of dengue to human. In this study, we propose and analyze a model describing the fundamental aspects of the competition between mosquitoes carrying Wolbachia and mosquitoes free of the parasite. We then use feedback control techniques to devise an introduction protocol which is proved to guarantee that the population converges to a stable equilibrium where the totality of mosquitoes carry Wolbachia.
Type de document :
Pré-publication, Document de travail
2015
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https://hal.inria.fr/hal-01261164
Contributeur : Pierre-Alexandre Bliman <>
Soumis le : lundi 25 janvier 2016 - 14:41:26
Dernière modification le : vendredi 31 août 2018 - 09:06:03

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  • HAL Id : hal-01261164, version 1
  • ARXIV : 1503.05216

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Pierre-Alexandre Bliman, Maria Soledad Aronna, Flávio Coelho, Moacyr Da Silva. Ensuring successful introduction of Wolbachia in natural populations of Aedes aegypti by means of feedback control. 2015. 〈hal-01261164〉

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