Abstract : In this article, we derive the Maxwell-Stefan formalism from the Boltzmann equation for mixtures for general cross-sections. The derivation uses the Hilbert asymptotic method for systems at low Knudsen and Mach numbers. We also formally prove that the Maxwell-Stefan coecients can be linked to the direct linearized Boltzmann operator for mixtures. That allows to compute the values of the Maxwell-Stefan diusion coecients with explicit and simple formulae with respect to the cross-sections. We also justify the specic ansatz we use thanks to the so-called moment method.