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Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation

Abstract : We propose a mathematical model for the DNA plasmids transport from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data.
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https://hal.inria.fr/hal-01349522
Contributor : Clair Poignard <>
Submitted on : Monday, November 28, 2016 - 2:20:45 PM
Last modification on : Monday, December 14, 2020 - 5:16:19 PM

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Michael Leguèbe, Maria G. Notarangelo, Monika Twarogowska, Roberto Natalini, Clair Poignard. Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation. [Research Report] RR-8939, Inria Bordeaux Sud-Ouest. 2016. ⟨hal-01349522v2⟩

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