. Amd-alliance and . International, What's Happening in AMD? An answer based on presentations at AAO's " Retina 2006: Emerging New Concepts, 2006.

H. L. Cook, P. J. Patel, and A. Tufail, Age-related macular degeneration: diagnosis and management, British Medical Bulletin, vol.85, issue.1, pp.127-149, 2008.
DOI : 10.1093/bmb/ldn012

G. S. Hageman, P. J. Luthert, N. H. Victor-chong, L. V. Johnson, D. H. Anderson et al., An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration, Progress in Retinal and Eye Research, vol.20, issue.6, pp.705-732, 2001.
DOI : 10.1016/S1350-9462(01)00010-6

A. C. Bird, N. M. Bressler, S. B. Bressler, I. H. Chisholm, G. Coscas et al., An international classification and grading system for age-related maculopathy and age-related macular degeneration, Survey of Ophthalmology, vol.39, issue.5, pp.367-374, 1995.
DOI : 10.1016/S0039-6257(05)80092-X

J. M. Sparrow, A. J. Dickinson, and A. M. Duke, The Wisconsin Age-related Macular Degeneration grading system: Performance in an independent centre, Ophthalmic Epidemiology, vol.32, issue.1, pp.49-55, 1997.
DOI : 10.1016/S0161-6420(91)32186-9

A. Mora, P. Vieira, and J. Fonseca, MD3RI a Tool for Computer-Aided Drusens Contour Drawing, Fourth IASTED International Conference on Biomedical Engineering - BIOMED2006, 2006.

A. D. Mora, P. M. Vieira, A. Manivannan, and J. M. Fonseca, Automated drusen detection in retinal images using analytical modelling algorithms, BioMedical Engineering OnLine, vol.10, issue.1, 2011.
DOI : 10.1137/0111030

S. Brunner, I. Krebs, U. Stolba, C. I. Falkner, S. Binder et al., Cataract Surgery in Nonexsudative Age-Related Macular -First Results of a Prospective, Randomized, Multicenter Trial (ECAM-1) Association for, p.169, 2005.

R. Klein, M. D. Davis, Y. L. Magli, P. Segal, B. E. Klein et al., The Wisconsin Age-related Maculopathy Grading System, Ophthalmology, vol.98, issue.7, pp.1128-1134, 1991.
DOI : 10.1016/S0161-6420(91)32186-9

D. W. Marquardt, An Algorithm for Least-Squares Estimation of Nonlinear Parameters, Journal of the Society for Industrial and Applied Mathematics, vol.11, issue.2, pp.431-441, 1963.
DOI : 10.1137/0111030

M. Sebag, E. Peli, and M. Lahav, Image analysis of changes in drusen area, Acta Ophthalmologica, vol.62, issue.5, pp.603-610, 1991.
DOI : 10.1111/j.1755-3768.1991.tb04847.x

R. Phillips, J. Forrester, and P. Sharp, Automated detection and quantification of retinal exudates, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.26, issue.2, pp.90-94, 1993.
DOI : 10.1007/BF00920219

W. H. Morgan, R. L. Cooper, I. J. Constable, and R. H. Eikelboom, Automated extraction and quantification of macular drusen from fundal photographs, Australian and New Zealand Journal of Ophthalmology, vol.41, issue.1, pp.7-12, 1994.
DOI : 10.1111/j.1442-9071.1994.tb01688.x

D. S. Shin, N. B. Javornik, and J. W. Berger, Computer-assisted, interactive fundus image processing for macular drusen quantitation11The authors have no proprietary interest in any aspect of this study., Ophthalmology, vol.106, issue.6, pp.1119-1125, 1999.
DOI : 10.1016/S0161-6420(99)90257-9

P. Soliz, M. P. Wilson, S. C. Nemeth, and P. Nguyen, <title>Computer-aided methods for quantitative assessment of longitudinal changes in retinal images presenting with maculopathy</title>, Medical Imaging 2002: Visualization, Image-Guided Procedures, and Display, pp.159-170, 2002.
DOI : 10.1117/12.466917

R. T. Smith, J. K. Chan, T. Nagasaki, U. F. Ahmad, I. Barbazetto et al., Automated Detection of Macular Drusen Using Geometric Background Leveling and Threshold Selection, Archives of Ophthalmology, vol.123, issue.2, pp.200-206, 2005.
DOI : 10.1001/archopht.123.2.200

H. P. Scholl, T. Peto, S. Dandekar, C. Bunce, W. Xing et al., Interand intra-observer variability in grading lesions of age-related maculopathy and macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology, pp.39-47, 2003.

J. R. Landis and G. G. Koch, The Measurement of Observer Agreement for Categorical Data, Biometrics, vol.33, issue.1, pp.159-174, 1977.
DOI : 10.2307/2529310