Technology in the THz frequency band has progressed rapidly in the last a few years. The THz frequency band offers greater communication bandwidth than at microwaves frequencies, and is imposing for nano-scale communications. Indeed, what makes THz waves interesting, is their possible applications because of their specific features. Traditional channel models for lower frequencies do not take into consideration specific properties as the very high molecular absorption or the very high reflection loss. In a propagation medium exhibiting a Giant Optical Activity, it is also important to derive the characteristics of the channel affected by chirality effects. This phenomenon occurs in particular material so-called chiralmetamaterials in (4–10) THz band. The main contribution of this paper consist in the analysis of specific parameters of a chiral-metamaterial, such as the relative electrical permittivity, magnetic permeability and chirality coefficients. These parameters will be considered for the channel model derivation both in Line-of-Sight and No Line-of-Sight propagation. The chiral effect affects the channel through the presence of spectral windows, due to peaks of resonance of chiral parameter. Performance analysis of the chirality-affected channel has been assessed in terms of (i) channel capacity, (ii) propagation delay, (iii) coherence bandwidth, and (iv) symbol rates, for different distances and propagation modes.