Time-coded neurotransmitter release at excitatory and inhibitory synapses

Abstract : Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released asynchronously, that is, after a delay following the spike, or spontaneously in the absence of a stimulus. The mechanisms underlying asynchronous and spontaneous neurotransmitter release remain elusive. Here, we describe a model of the exocytotic cycle of vesicles at excitatory and inhibitory synapses that accounts for all modes of vesicle release as well as short-term synaptic plasticity (STSP). For asynchronous release, the model predicts a delayed inertial protein unbinding associated with the SNARE complex assembly immediately after vesicle priming. Experiments are proposed to test the model’s molecular predictions for differential exocytosis. The simplicity of the model will also facilitate large-scale simulations of neural circuits.
Document type :
Journal articles
Liste complète des métadonnées

https://hal.inria.fr/hal-01386149
Contributor : Mathieu Desroches <>
Submitted on : Saturday, October 22, 2016 - 10:47:06 PM
Last modification on : Thursday, January 11, 2018 - 5:04:00 PM

Links full text

Identifiers

Collections

Citation

Serafim Rodrigues, Mathieu Desroches, Martin Krupa, Jesus Cortes, Terrence J. Sejnowski, et al.. Time-coded neurotransmitter release at excitatory and inhibitory synapses. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2016, 113 (8), pp.E1108-E1115. ⟨http://www.pnas.org/content/113/8/E1108.short⟩. ⟨10.1073/pnas.1525591113⟩. ⟨hal-01386149⟩

Share

Metrics

Record views

231