How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation

Abstract : Aims Loss of side-to-side electrical connections between atrial muscle bundles is thought to underlie conduction disturbances predisposing to atrial fibrillation (AF). Putatively, disruption of electrical connections occurs not only within the epicardial layer but also between the epicardial layer and the endocardial bundle network, thus impeding transmural conductions (‘breakthroughs’). However, both clinical and experimental studies have shown an enhancement of breakthroughs during later stages of AF. We tested the hypothesis that endo-epicardial uncoupling enhances endo-epicardial electrical dyssynchrony, breakthrough rate (BTR), and AF stability. Methods and results In a novel dual-layer computer model of the human atria, 100% connectivity between the two layers served as healthy control. Atrial structural remodelling was simulated by reducing the number of connections between the layers from 96 to 6 randomly chosen locations. With progressive elimination of connections, AF stability increased. Reduction in the number of connections from 96 to 24 resulted in an increase in endo-epicardial dyssynchrony from 6.6 ± 1.9 to 24.6 ± 1.3%, with a concomitant increase in BTR. A further reduction to 12 and 6 resulted in more pronounced endo-epicardial dyssynchrony of 34.4 ± 1.15 and 40.2 ± 0.52% but with BTR reduction. This biphasic relationship between endo-epicardial coupling and BTR was found independently from whether AF was maintained by re-entry or by ectopic focal discharges. Conclusion Loss of endo-epicardial coupling increases AF stability. There is a biphasic relation between endo-epicardial coupling and BTR. While at high degrees of endo-epicardial connectivity, the BTR is limited by the endo-epicardial synchronicity, at low degrees of connectivity, it is limited by the number of endo-epicardial connections.
Type de document :
Pré-publication, Document de travail
2016
Liste complète des métadonnées

https://hal.inria.fr/hal-01386915
Contributeur : Mark Potse <>
Soumis le : lundi 5 décembre 2016 - 22:17:06
Dernière modification le : mercredi 10 janvier 2018 - 14:19:09
Document(s) archivé(s) le : mardi 21 mars 2017 - 03:39:09

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales 4.0 International License

Identifiants

Collections

Citation

Ali Gharaviri, Sander Verheule, Jens Eckstein, Mark Potse, Pawel Kuklik, et al.. How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation. 2016. 〈hal-01386915〉

Partager

Métriques

Consultations de la notice

74

Téléchargements de fichiers

59