A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis

Abstract : Exploration of developmental mechanisms classically relies on analysis of pattern regularities. Whether disorders induced by biological noise may carry information on building principles of developmental systems is an important debated question. Here, we addressed theoretically this question using phyllotaxis, the geometric arrangement of plant aerial organs, as a model system. Phyllotaxis arises from reiterative organogenesis driven by lateral inhibitions at the shoot apex. Motivated by recurrent observations of disorders in phyllotaxis patterns, we revisited in depth the classical deterministic view of phyllotaxis. We developed a stochastic model of primordia initiation at the shoot apex, integrating locality and stochasticity in the patterning system. This stochastic model recapitulates phyllotactic patterns, both regular and irregular, and makes quantitative predictions on the nature of disorders arising from noise. We further show that disorders in phyllotaxis instruct us on the parameters governing phyllotaxis dynamics, thus that disorders can reveal biological watermarks of developmental systems.
Type de document :
Article dans une revue
eLife, eLife Sciences Publication, 2016, 71, pp.50. 〈10.7554/eLife.14093.048〉
Liste complète des métadonnées

Littérature citée [64 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01390155
Contributeur : Christophe Godin <>
Soumis le : jeudi 3 novembre 2016 - 19:53:05
Dernière modification le : jeudi 24 mai 2018 - 15:59:21
Document(s) archivé(s) le : samedi 4 février 2017 - 12:43:22

Fichier

Refahi2016 eLife.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Yassin Refahi, Géraldine Brunoud, Etienne Farcot, Alain Jean-Marie, Minna Pulkkinen, et al.. A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis. eLife, eLife Sciences Publication, 2016, 71, pp.50. 〈10.7554/eLife.14093.048〉. 〈hal-01390155〉

Partager

Métriques

Consultations de la notice

994

Téléchargements de fichiers

143