Next generation metronomic chemotherapy - report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6 - 8 May 2016, Mumbai

Abstract : The 5th Biennial Metronomic and Anti-angiogenic Therapy Meeting was held on 6th – 8th May in the Indian city of Mumbai. The meeting brought together a wide range of clinicians and researchers interested in metronomic chemotherapy, anti-angiogenics, drug repurposing and combinations thereof. Clinical experiences, including many from India, were reported and discussed in three symposia covering breast cancer, head and neck cancers and paediatrics. On the pre-clinical side research into putative mechanisms of action, and the interactions between low dose metronomic chemotherapy and angiogenesis and immune responses, were discussed in a number of presentations. Drug repurposing was discussed both in terms of clinical results, particularly with respect to angiosarcoma and high-risk neuroblastoma, and in pre-clinical settings, particularly the potential for peri-operative interventions. However, it was clear that there remain a number of key areas of challenge, particularly in terms of definitions, perceptions in the wider oncological community, mechanisms of action and pre- dictive biomarkers. While the potential for metronomics and drug repurposing in low and middle income countries remains a key theme, it is clear that there is also considerable potential for clinically relevant improvements in patient outcomes even in high income economies.
Document type :
Journal articles
Complete list of metadatas

Cited literature [115 references]  Display  Hide  Download

https://hal.inria.fr/hal-01392473
Contributor : Sebastien Benzekry <>
Submitted on : Friday, November 4, 2016 - 2:54:13 PM
Last modification on : Tuesday, October 22, 2019 - 9:12:11 AM
Long-term archiving on : Sunday, February 5, 2017 - 2:08:30 PM

File

Pantziarka_16_Next generation ...
Files produced by the author(s)

Identifiers

Collections

Citation

Pan Pantziarka, Lisa Hutchinson, Nicolas André, Sébastien Benzekry, Francesco Bertolini, et al.. Next generation metronomic chemotherapy - report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6 - 8 May 2016, Mumbai. Ecancermedicalscience, 2016, 10, ⟨10.3332/ecancer.2016.689⟩. ⟨hal-01392473⟩

Share

Metrics

Record views

747

Files downloads

1099