Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Mathieu Angin; Glenn Wong; Laura Papagno; Pierre Versmisse; Annie David; Charles Bayard; Bénédicte Charmeteau-de Muylder; Amel Besseghir; Rodolphe Thiébaut; Faroudy Boufassa; Gianfranco Pancino; Delphine Sauce; Olivier Lambotte; Francoise Brun-Vézinet; Sophie Matheron; Sarah L Rowland-Jones; Rémi Cheynier; Asier Sáez-Cirión; Victor Appay

doi:10.4049/jimmunol.1600693

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Mathieu Angin ¹ Glenn Wong ^{2, 3} Laura Papagno ³ Pierre Versmisse ¹ Annie David ¹ Charles Bayard ³ Bénédicte Charmeteau-de Muylder ⁴ Amel Besseghir ⁵ Rodolphe Thiébaut ⁵ Faroudy Boufassa ⁶ Gianfranco Pancino ¹ Delphine Sauce ³ Olivier Lambotte ⁷ Francoise Brun-Vézinet ^{8, 9} Sophie Matheron ¹⁰ Sarah L Rowland-Jones ² Rémi Cheynier ⁴ Asier Sáez-Cirión ^{1, *} Victor Appay ³

* Corresponding author

1 HIV, Inflammation et persistance

2 Nuffield Department of Clinical Medicine [Oxford]

3 CIMI - Centre d'Immunologie et de Maladies Infectieuses

4 IC UM3 (UMR 8104 / U1016) - Institut Cochin

5 SISTM - Statistics In System biology and Translational Medicine

Epidémiologie et Biostatistique [Bordeaux], Inria Bordeaux - Sud-Ouest

6 CESP - Centre de recherche en épidémiologie et santé des populations

7 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes

8 UPD7 - Université Paris Diderot - Paris 7

9 Service de Virologie [CHU Bichat]

10 AP-HP - Hôpital Bichat - Claude Bernard [Paris]

Abstract : Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8(+) T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8(+) T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8(+) T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag-specific CD8(+) T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8(+) T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4(+) T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Santé publique et épidémiologie

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