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Journal articles
Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.
Mathieu Angin
1
Glenn Wong
2, 3
Laura Papagno
3
Pierre Versmisse
1
Annie David
1
Charles Bayard
3
Bénédicte Charmeteau-de Muylder
4
Amel Besseghir
5
Rodolphe Thiébaut
5
Faroudy Boufassa
6
Gianfranco Pancino
1
Delphine Sauce
3
Olivier Lambotte
7
Francoise Brun-Vézinet
8, 9
Sophie Matheron
10
Sarah L Rowland-Jones
2
Rémi Cheynier
4
Asier Sáez-Cirión
1, *
Victor Appay
3
*
Corresponding author
5
SISTM - Statistics In System biology and Translational Medicine
Epidémiologie et Biostatistique [Bordeaux], Inria Bordeaux - Sud-Ouest
Annie David 1
Author
Charles Bayard 3
Author
Bénédicte Charmeteau-de Muylder 4
Author
Amel Besseghir 5
Author
Rodolphe Thiébaut 5
Author IdHAL : rodolphe-thiebaut ORCID : https://orcid.org/0000-0002-5235-3962
Faroudy Boufassa 6
Author
Gianfranco Pancino 1
Author
Delphine Sauce 3
Author IdHAL : delphine-sauce ORCID : https://orcid.org/0000-0003-4596-7373
Olivier Lambotte 7
Author
Francoise Brun-Vézinet 8, 9
Author
Sophie Matheron 10
Author
Sarah L Rowland-Jones 2
Author
Rémi Cheynier 4
Author
Asier Sáez-Cirión 1
Correspondent author IdHAL : asier-saez-cirion ORCID : https://orcid.org/0000-0003-2406-7536
Victor Appay 3
Author
1
HIV, Inflammation et persistance (Département Virologie, 25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
Nuffield Department of Clinical Medicine [Oxford] (Oxford OX3 - United Kingdom)
- University of Oxford [Oxford] (Wellington Square, Oxford OX1 2JD - United Kingdom)
3
CIMI - Centre d'Immunologie et de Maladies Infectieuses (91 Boulevard de l'hôpital 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : ERL8255 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1135 (101, rue de Tolbiac, 75013 Paris - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
4
IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)
- UPD5 - Université Paris Descartes - Paris 5 : UM 3 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1016 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8104 (France)
5
SISTM - Statistics In System biology and Translational Medicine (200, avenue de la Vieille Tour
33405 Talence cedex
146 Rue Léo Saignat
33076 Bordeaux cedex
- France)
- Epidémiologie et Biostatistique [Bordeaux] (146, rue Léo-Saignat 33076 Bordeaux - France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U897 (101, rue de Tolbiac, 75013 Paris - France)
- Inria Bordeaux - Sud-Ouest (200, avenue de la Vieille Tour,
33405 Talence - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
6
CESP - Centre de recherche en épidémiologie et santé des populations (16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France - France)
- UVSQ - Université de Versailles Saint-Quentin-en-Yvelines : UMR U1018 (55 avenue de Paris - 78035 Versailles cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1018 (101, rue de Tolbiac, 75013 Paris - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Paul Brousse (12 Avenue Paul Vaillant Couturier, 94800 Villejuif - France)
7
IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes (Site de l'Hôpital de Bicêtre - Faculté de Médecine Paris Sud - 63 rue Gabriel Péri 94276 Le Kremlin-Bicêtre Cedex.
Site du CEA de Fontenay-aux-Roses - 10, route du Panorama - BP 6 - 92265 Fontenay-aux-Roses. - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1184 (101, rue de Tolbiac, 75013 Paris - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/IMETI (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
8
UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
9
Service de Virologie [CHU Bichat] (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- AP-HP - Hôpital Bichat - Claude Bernard [Paris] (46 Rue Henri Huchard, 75018 Paris - France)
10
AP-HP - Hôpital Bichat - Claude Bernard [Paris] (46 Rue Henri Huchard, 75018 Paris - France)
Abstract : Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8(+) T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8(+) T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8(+) T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag-specific CD8(+) T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8(+) T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4(+) T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.
Document type :
Journal articles
Complete list of metadatas
https://hal.inria.fr/hal-01406621
Contributor : Sandrine Darmigny <>
Submitted on : Monday, April 24, 2017 - 11:14:29 AM
Last modification on : Wednesday, October 14, 2020 - 3:48:03 AM
Long-term archiving on: : Tuesday, July 25, 2017 - 3:00:17 PM
Contributor : Sandrine Darmigny <>
Submitted on : Monday, April 24, 2017 - 11:14:29 AM
Last modification on : Wednesday, October 14, 2020 - 3:48:03 AM
Long-term archiving on: : Tuesday, July 25, 2017 - 3:00:17 PM
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Identifiers
- HAL Id : hal-01406621, version 1
- DOI : 10.4049/jimmunol.1600693
- PUBMED : 27566819
Collections
PASTEUR | CNRS | UNIV-PARIS5 | UPMC | UVSQ | CESP | CIMI | CEA | USPC | UNIV-PARIS-SACLAY | INRIA | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-PARIS7 | UNIV-PARIS | UP-SANTE
Citation
Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, et al.. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 197 (7), pp.2787-95. ⟨10.4049/jimmunol.1600693⟩. ⟨hal-01406621⟩
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