Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Mathieu Angin 1 Glenn Wong 2, 3 Laura Papagno 3 Pierre Versmisse 1 Annie David 1 Charles Bayard 3 Bénédicte Charmeteau-de Muylder 4 Amel Besseghir 5 Rodolphe Thiébaut 5 Faroudy Boufassa 6 Gianfranco Pancino 1 Delphine Sauce 3 Olivier Lambotte 7 Françoise Brun-Vézinet 8, 9 Sophie Matheron 10 Sarah L Rowland-Jones 2 Rémi Cheynier 4 Asier Sáez-Cirión 1, * Victor Appay 3
* Corresponding author
1 HIV, Inflammation et persistance
2 Nuffield Department of Clinical Medicine [Oxford]
3 CIMI - Centre d'Immunologie et de Maladies Infectieuses
4 IC UM3 (UMR 8104 / U1016) - Institut Cochin
5 SISTM - Statistics In System biology and Translational Medicine
Epidémiologie et Biostatistique [Bordeaux], Inria Bordeaux - Sud-Ouest
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
8 UPD7 - Université Paris Diderot - Paris 7
9 Service de Virologie [CHU Bichat]
10 Hôpital Bichat - Claude Bernard
Abstract : Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8(+) T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8(+) T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8(+) T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag-specific CD8(+) T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8(+) T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4(+) T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.
Document type :
Journal articles
Liste complète des métadonnées

Cited literature [51 references]  Display  Hide  Download
https://hal.inria.fr/hal-01406621
Contributor : Sandrine Darmigny <>
Submitted on : Monday, April 24, 2017 - 11:14:29 AM
Last modification on : Thursday, April 11, 2019 - 4:02:20 PM
Document(s) archivé(s) le : Tuesday, July 25, 2017 - 3:00:17 PM

File

Angin-Wongetal-20160715-HA-mer...
Files produced by the author(s)

Licence

Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License

Identifiers

Collections

PASTEUR | UNIV-PARIS5 | UPMC | UVSQ | CESP | CIMI | CEA | USPC | UNIV-PARIS-SACLAY | INRIA | INRIA-BORDEAUX | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-PARIS7

Citation

Mathieu Angin, Glenn Wong, Laura Papagno, Pierre Versmisse, Annie David, et al.. Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 197 (7), pp.2787-95. ⟨10.4049/jimmunol.1600693⟩. ⟨hal-01406621⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

1461

Files downloads

162

Contact


archive-ouverte@inria.fr